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Showing 1‐28 of 621
Blog
3 min read
Inhalable mRNA lipid nanoparticle powders via spray drying: is it possible?
Dry powder inhaled formulations of small molecule drugs are a mainstay of treatment for respiratory diseases such as asthma and COPD, and it’s a field where we have extensive experience here at Lonza
Webinar (on-demand)
55 min read
Cracking Complexity: Learnings from 70+ Bispecific Antibody Programs
The biologics pipeline is becoming increasingly complex as next generation antibody formats, including bispecific antibodies, move rapidly toward the clinic. For early stage biotech teams, this complexity often translates into uncertainty around where th...
Webinar (on-demand)
30 min read
Accelerating Success: Advanced Developability Strategies for Bioconjugates ​and ADCs
In this on-demand webinar, our experts explore how Lonza’s Early Development Services support the successful progression of bioconjugates—such as antibody–drug conjugates (ADCs)—from late discovery through early preclinical development. Discover how ...
Webinar (on-demand)
49 min read
The 24 Months Before CGT Launch
Every second counts: what real cell and gene therapy launches teach us For cell and gene therapies (CGTs), the path from a successful clinical readout to reliable commercial supply remains one of the most technically and operationally demanding trans...
Webinar (on-demand)
Faster Clones, Simpler Process: What’s Changing in CHO Expression?
This webinar will discuss the latest innovation in the GS® Expression System. We will discuss how Lonza’s advanced vector technology elevates protein expression performance through improved glutamine synthetase selection stringency combined with a high-st...
Webinar (on-demand)
in vivo CAR-T And Gene Editing: The Manufacturing Reality Behind The Promise
In vivo CAR-T is moving fast, and so are the manufacturing challenges behind it. LNPs and viral vectors are both gaining ground as delivery platforms, but each comes with a distinct set of constraints that are already shaping which programs will scale an...
White paper
Avoiding the Pitfalls: Five Lessons for Cell Therapy Manufacturing Success
This white paper explores five common manufacturing and operational challenges that can delay or disrupt the transition from clinical development to commercial production in cell therapy. Designed for professionals involved in bringing cell therapy produc...
Article
7 min read
Expert Q&A: Navigating Complexity in Modern Small Molecule Development
Interview with our Lonza subject matter expert in small molecule development.
Webinar (on-demand)
55 min read
Early Developability Assessment for Antibody-based Therapeutics
In this on-demand webinar, Head of Immunology, Noel Smith, PhD, explores how our integrated toolbox — combining in silico screening, the GS® expression system, and human immune cell assays — supports early identification of developability and immunogenici...
Webinar (on-demand)
55 min read
From Insights to Impact: Predictive Models and PAT for More Efficient and Robust Biologics Manufacturing
Scaling biologics from development to commercial manufacturing requires precision, consistency, and control across both drug substance and drug product processes. Variability during scale-up—particularly in bioreactor operations and lyophilization—can i...
Poster
Advancing Lentiviral Genome Integrity and Titer Analysis Via Two Dimensional Reverse Transcription-digital PCR (2D RT-dPCR)
Lentiviral vectors (LVVs) are powerful and versatile gene‑transfer tools widely used in both ex vivo and in vivo cell and gene therapies. Traditional single‑channel dPCR or qPCR assay only provides limited information of the viral genome and cannot distin...
Poster
Establishment of a High‑Yield Stable Producer Cell Line for CD19 Chimeric Antigen Receptor-Based Lentiviral Vector Manufacturing
Lentiviral vectors (LVVs) are increasingly needed for gene and cell therapies, but transient transfection limits scalability and consistency. To address this need, we developed an inducible stable LVV producer cell line using a CD19 CAR as the gene‑of‑int...
Poster
A Robust System for High-titer, Platform-agnostic AAV Production in HEK293 Cell Lines
Successful Adeno-Associated Virus (AAV) programs requires careful choosing of critical production platform components such as engineered cell lines, plasmids and transfection reagents. Amongst them, cell culture medium being the environment of all upstream AAV production steps, is foundational to productivity and efficiency of packaging. Here we present a flexible cell culture media system that simplifies process development and optimization by demonstrating broad compatibility with commercially available AAV production components. This same system supports process development strategies that yield viral titers of >...
Poster
Accelerating Construction of AAV Stable Producer Cell Line with Integrated Process Development
AAV producer cell lines (PCLs) offer higher and consistent productivity, better scalability and process robustness, reduced cost of goods at scale compared to transient transfection based production. However, PCL adoption is often restrained by the extend...
Poster
Immunogenicity Risk Assessment of mRNA Therapeutics - Key Considerations When Assessing Preclinical Immunogenicity Risk
This poster highlights Lonza’s approach to preclinical immunogenicity risk assessment for mRNA/LNP therapeutics using human in vitro assays. Immunogenicity is influenced by multiple product‑ and process‑related factors, many of which can be evaluated earl...
Poster
Comprehensive Characterization and in vitro Functionality Study of Small Extracellular Vesicles Isolated by Different Purification Methods from Mesenchymal Stem Cell Cultures
Mesenchymal stem cells (MSCs) exhibit therapeutic properties, which have been attributed to their secretome, the set of secreted factors comprising cytokines, growth factors, and extracellular vesicles (EVs). In particular, small extracellular vesicles (s...
R&D Blog post
4 min read
Collaborative Innovation: Machine Learning for Better Glucose Monitoring
Every day in a development lab unfolds through a series of routine checks that keep experiments moving and data flowing. Glucose monitoring is a perfect example: a quick measurement that, when repeated across many cultures, becomes a meaningful though lab...
Technical/Service brief
1 min read
Bending the AAV Manufacturing Cost Curve Through Scalable Platform Innovation, Productivity Gains, and Analytical Insight
Move Beyond Transient Transfection Transient transfection has enabled early AAV development, but it introduces inherent limitations at scale—high cost of goods, supply chain dependency on GMP plasmids, process variability, and increasing ope...
White paper
2 min read
Bridging Studies for AAV Producer Cell Line Adoption: Regulatory and Development Perspectives
Adeno-associated virus (AAV) gene therapies have demonstrated clear clinical potential, with multiple products approved globally; however, increasing pipeline complexity and expansion into more prevalent indications are exposing limitations of transient t...
Webinar (on-demand)
27 min read
What It Takes to Scale: Translating Microbial Early Decisions into Commercial Readiness
Scaling up microbial manufacturing remains one of the most complex and often underestimated challenges across the development lifecycle. While many programs advance successfully through early stages, delays and complications frequently ...
CDMO Notes Blog post
8 min read
Rethinking MSX Selection: Optimizing Glutamine Synthetase Expression for Enhanced Bioproduction
As therapeutic proteins become more complex, selection strategies must evolve to support stability, predictability, and efficient development. Traditional MSX-based approaches​​​​ can introduce variability that challenges long-term performance and scale-...
Webinar (on-demand)
50 min read
From DNA to IND in as Little as 6 Months: Fast to Clinic, Designed to Scale, Backed by Experience
Getting to IND faster has become an industry expectation—but acceleration without the right strategy can amplify risk. In this on-demand webinar, Lonza experts show how sponsors can take biologic programs from DNA to IND readiness in as little as 6 months...
Article
8 min read
Building Quality by Design for Multi-Specific Therapeutic Proteins
As molecular complexity increases, so do the challenges associated with developability, manufacturability, and clinical safety. Embedding quality by design (QbD) principles early in development is therefore essential to de-risk these programs, support eff...
e-book
8 min read
A Guide for CGT Developers in Switching CDMO Partners
This playbook is a how-to guide in assessing potential CDMOs when initiating a switch to a new secondary or primary CDMO partner. Whether you’re looking to source a secondary CDMO or looking for a primary CDMO, you’re not alone. The single contract develo...
White paper
10 min read
Engineering Extracellular Vesicles (Exosomes) for Nucleic Acid Delivery
exoASO‑STAT6® Exosomes As a Case Study   Delivering nucleic acids safely and precisely remains one of the biggest challenges in advanced therapeutics. This white paper explores how engineered extracellular vesicles, also known as exosomes, are being...
Webinar (on-demand)
40 min read
Accelerating Bioconjugate Development Through Rapid Exploratory Screening and Analytics
Early-stage development of antibody–drug conjugates (ADCs) and other complex bioconjugates demands speed, clarity, and confidence. To keep preclinical and first-in-human programs on track, development teams need robust processes and reliable analytical ...
Podcast
25 min read
Dry Powder for Intranasal Delivery
Intranasal dry powders are gaining attention as a promising alternative for drug delivery—offering a non-invasive route with the potential to expand how biologics and other therapies are administered. In this podcast episode, based on an expert-led we...
White paper
10 min read
Enzymatic Conjugation Strategies for Next‑Generation ADCs
Antibody–drug conjugates (ADCs) offer a targeted approach to cancer treatment, yet many candidates face clinical setbacks due to heterogeneity, linker instability, and design limitations. As only a small proportion of ADC programs reac...