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Showing 1‐28 of 500
Article
10 min read
Streamlining early phase drug development with continuous flow technologies
As small molecule complexity increases, early-stage development faces new challenges that demand innovative solutions. At Lonza Advanced Synthesis the continuous flow process is integrated into early phase development, allowing for optimization of chemica...
Poster
3 min read
Designing a Plug-and-Play System to Produce Engineered Extracellular Vesicles
Extracellular vesicles (EVs), including exosomes, are being studied extensively and have emerged as a promising novel technology for the delivery of complex therapeutic payloads such as nucleic acids or proteins. EVs are naturally occurring within the bod...
Poster
5 min read
Plasmid Engineering and Process Development to Improve Self-Complementary AAV Productivity
Self-complementary AAV (scAAV) vectors were developed by mutating one of the ITRs to form double-stranded genome. Unlike traditional single-stranded AAVs (ssAAV), scAAVs can enhance gene expression efficiency by bypassing the need for second-strand synthe...
Poster
3 min read
Development of high-performing stable producer cell lines for therapeutic AAV vector manufacturing
Attributed to their safety profiles and transduction efficiencies, recombinant Adeno-associated virus (AAV) vectors are widely used for treatment of human genetic diseases. However, the high cost and low productivity in AAV vector manufacturing process limit the clinical and commercial development of these life-changing therapies for more patients. Recently, we reported the development of high-performing, HEK293 cell based, helper virus-free AAV stable producer cell lines (PCL) that significantly increased the AAV productivity (>...
Poster
Adeno-associated virus characterization using nanopore long read sequencing and analysis
Recombinant adeno-associated virus (rAAV) has become a leading vector for in vivo gene delivery. The quality of the AAV product is crucial for the success of gene therapy, and thorough understanding of the viral genome sequence is becoming essential for e...
Poster
5 min read
Large-Scale High Titer Lentiviral Production Using Lonza's Suspension Transient Transfection Platform
Lentivirus vector (LVV) is a major player in cell and gene therapies. It efficiently transduces both dividing and non-dividing cells and is able to incorporate large transgenes, making it a versatile viral vector for a number of applications where gene de...
Interview
10 min read
Q&A on large-scale commercial expansion at Lonza's Stein facility
Are you a biopharmaceutical or biotech professional looking to stay ahead in the industry? Download our comprehensive Q&A-style interview to gain exclusive insights into our significant capacity expansion at our Stein, Switzerland facility. What's Inside...
Poster
5 min read
Novel synthetic production phase promoter for enhanced titre, product quality and expression stability in CHO cells
In this scientific poster, we demonstrate the development of a novel synthetic gene promoter designed for CHO cells. Available as part of the GSquad® Pro vector system, the promoter demonstrates desirable bioproduction characteristics compared to the CMV ...
Technical/Service brief
10 min read
Novel synthetic fusion promoter for improved GS-CHO expression of biotherapeutics
Historically, advancements in CHO-based recombinant protein production have been driven predominantly by process development, and whilst these efforts have delivered significant gains, they have also highlighted a need to optimize additional process input...
White paper
15 min read
Navigating the development of dry powder for inhalation
Interest in pulmonary/nasal routes for local delivery has significantly increased over the last decade owing to challenges faced in the delivery of molecules with poor solubility, systemic side effects, or new modalities such as biologics. This increasing...
White paper
5 min read
Innovations in linking rational design and material-sparing strategies for enabled intermediates and their drug products
Did you catch our insightful webinar on Linking rational design and material-sparing strategies for enabled intermediates and their drug products? If not, or if you're looking for a concise recap of the key discussions, our new executive summary paper is ...
Presentation (on-demand)
23 min read
Challenging your AAV productivity and packaging efficiencies through a validated platform
AAV transient and stable cell line platforms represent a leap into next-generation technologies that are set to drive gene therapy commercialization. Selecting the right manufacturing approach for AAV production is key to meeting productivity and scalabil...
Webinar (on-demand)
End-to-end regulatory CDMO solutions: development, manufacturing, and approval
Navigating the journey from drug development to market can feel like a maze, with each step presenting unique regulatory hurdles. That's why we hosted our insightful webinar, "End-to-end regulatory CDMO solutions: development, manufacturing, and approval,...
White paper
4 min read
Seamless commercial tech transfers in OSD manufacturing
Remember our insightful webinar on Commercial tech transfers in OSD manufacturing? If you missed it, or want a short recap of the key takeaways, our comprehensive executive summary paper is now available. This paper distills the essential discussions and ...
CDMO Notes Blog post
8 min read
Using bespoke downstream processing strategies for the purification of complex novel protein-based therapeutics
Discover how Lonza's innovative downstream processing strategies can help you overcome the challenges of purifying complex novel therapeutics, ensuring optimal product quality and efficiency in bringing your molecules to the clinic.
Webinar (on-demand)
Commercial Tech Transfers in OSD Manufacturing
This webinar explores the critical aspects of manufacturing commercial tech transfers for the manufacture of oral solid dosage (OSD) products. It provides insights into the progression of process validation for existing commercial products, ensuring consi...
R&D Blog post
4 min read
In-use stability and compatibility of Biologics – How to safely administer an effective medicinal product
Ensuring that patients receive the highest quality treatment under the best possible conditions is a fundamental priority in drug development.
Webinar (on-demand)
50 min read
Rapid delivery of toxicological study material: The new critical path for accelerating biopharmaceutical drug development
With ever-increasing speed from DNA to IND, the window for toxicological data generation is becoming shorter and more critical. This necessitates innovative solutions to expedite the delivery of materials required for these vital studies, upon which an IN...
White paper
5 min read
The Role of Excipients in Inhaled Biologics
The field of inhaled biologics is rapidly expanding, with both dry and liquid formulations of proteins, peptides, and nucleic acids gaining traction in clinical and commercial applications. Excipients are vital for ensuring the stability, safety, and eff...
CDMO Notes Blog post
6 min read
Accelerated Tox Offerings: A Recipe for Streamlining IND Applications
Accelerating the timeline to tox material can significantly enhance the drug development process, enabling faster IND submissions and providing crucial time savings for toxicology studies.
Webinar (on-demand)
15 min read
Lonza Drug Product OPCU Capacity Update
Explore Lonza's end-to-end Drug Product capabilities along the full life cycle, seamlessly integrated with the drug substance network across biologic modalities. This presentation will highlight recent expansions at the Stein site in Switzerland, includin...
Webinar (on-demand)
55 min read
De-Risking Early Phase Micronization with Integrated Solid Form Selection
Achieving the right particle size for respiratory drug delivery is crucial, and jet milling is a key technique. But how do you choose the right API solid form (salt, cocrystal, or solvate) for successful micronization and high yields? This webinar o...
Article
5 min read
Accelerating Drug Development with Precision Powder Micro-Dosing
Drive innovation in early-stage drug development with precision powder micro-dosing.
Webinar (on-demand)
30 min read
Producing Engineered Extracellular Vesicles with a Platform Approach
In this webinar, we'll discuss materials and methods to enable the expression of biomolecules on EVs. Data will be shared for using protein scaffolds, such as PTGFRN and BASP-1, that are clinically proven to effectively load therapeutic proteins on the su...
R&D Blog post
3 min read
Delivering a consistently excellent service with advanced process technologies
As a chemical engineer, it’s perhaps unsurprising that I find it immensely satisfying to use technology to solve problems. Over the past 20 years, I have built my career around finding better processes and techniques for pharmaceutical manufacturing by it...
CDMO Notes Blog post
6 min read
A Faster Path to the Clinic: Accelerating Biologics Development with Integrated Solutions
How Lonza’s team are helping to revolutionise the path to Biologics INDs, with an accelerated approach to drug development
Podcast
2 min read
A View On mRNA Encapsulation (S04 E03)
In this episode, we are joined by three experts—Christoph Hein (Fraunhofer IPK), Bern-hard Bobusch (FDX Fluid Dynamix), and Sönke Stocker (Lonza)—to explore how ad-vanced fluidics, encapsulation techniques, and a truly collaborative approach are paving th...
Webinar (on-demand)
60 min read
Accelerating Clinical Development: Modern Tools in Process Chemistry
This webinar explores how Lonza leverages High-Throughput Experimentation (HTE) and a model-based approach to enhance process development in early-phase projects. Designed to address the unique challenges faced by early-phase customers, the session will ...