A customized and fit-for-purpose particle engineering service as part of our integrated drug substance and drug product offering. Each offering is in place to help advance your compound from concept to clinical and commercialization.
You can access:
Our particle engineering services using spray drying and hot-melt extrusion are located at our Bend (US) site.
A Flexible Platform
The SDD platform incorporates compositions, processes and dosage forms designed and proven to meet performance, stability and manufacturability requirements for a diverse range of compounds. With our integrated product development approach, we can manufacture phase appropriate SDD formulations for each stage of development, from preclinical to late-stage development and commercial production. Drug product intermediates can be formulated into capsules, tablets and other forms, supporting broader bioavailability enhancement strategies.
A Streamlined Formulation Process
Our approach provides rapid and reliable advancement of low-solubility compounds and supports customers seeking enhanced bioavailability solutions.
A Proven Technology
SDD technology has been proven in thousands of compounds and tens of commercial products, resulting in significantly improved bioavailability, typically from three to 15-fold — a core bioavailability enhancement pathway.
Proven technology While there are several platform technologies and manufacturing techniques to produce amorphous solid dispersions, hot-melt extrusion (HME) is a leading approach based on mature process understanding, small process footprint and continuous operation. It is readily scalable and supports customers needing a bioavailability enhancement service.
Extensive experience By combining our depth of solubilization technologies with our fundamental understanding of pharmacokinetics, we can rapidly identify, prototype and optimize an amorphous solid dispersion formulation that improves the bioavailability of a low aqueous solubility drug substance — a key component of enhanced bioavailability solutions.
Lonza applies a tailored, science-first approach to improve the bioavailability of low-solubility compounds. Using a broad toolkit of proven technologies and deep expertise, Lonza helps you rapidly identify and develop the right formulation to enhance absorption and accelerate your path to clinic and commercialization.
Lonza offers a range of proven bioavailability enhancement technologies, including spray-dried dispersions (SDD) and hot-melt extrusion (HME). These approaches are selected based on your molecule’s specific needs to improve solubility, stability, and overall performance.
Bioavailability enhancement should be considered as early as possible—particularly since around 70% of new compounds face solubility or permeability challenges.
Early, data-driven assessment using drug substance (DS)-sparing methodologies allows you to efficiently evaluate key properties such as solubility and permeability, even when material is limited. These insights can be further strengthened with physiologically based biopharmaceutics modeling (PBBM) to understand the underlying mechanisms driving poor bioavailability.
By identifying whether limitations stem from solubility, permeability, or other factors, you can make informed decisions and select the most appropriate bioavailability enhancement (BAE) technology. This targeted approach reduces development risk, avoids unnecessary formulation work, and supports faster, more predictable progression from discovery to clinical development.
Lonza’s technologies—such as spray-dried dispersions—have been proven across thousands of compounds to deliver significant improvements in bioavailability, typically ranging from 3- to 15-fold. This enables better drug absorption and helps unlock the full potential of your molecule.
Yes, Lonza provides an integrated product development approach, supporting your molecule from early feasibility studies through clinical development and commercial manufacturing. This end-to-end expertise helps reduce complexity, streamline development, and accelerate time to market.