Lead Scientist R&D Process Development
United Kingdom, Slough

Job Title – Lead Scientist

Location: Slough, UK
 

Today, Lonza is a global leader in life sciences operating across three continents. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that’s the kind of work we want to be part of.

Lonza Pharma & Biotech has an excellent opportunity for a Lead Scientist to join the R&D group working on lab scale bioreactor process development and automation at their Slough, UK location.

Role Purpose:

The purpose of the role is to maintain Lonza Pharma & Biotech as a leading contract manufacturer through the development and optimization of fed-batch and perfusion process technologies at lab scale employing automation engineering solution. 

Key responsibilities:

  • Working closely with the upstream R&D team; plans and executes several complex (non-routine) lab-scale fed batch and perfusion bioreactor process development and optimization experiments
  • Experience with mechanistic modelling for CHO cell bioprocessing
  • Set up, operate, and maintain lab-scale bioreactors for mammalian cell culture. Monitor bioprocess parameters and ensure optimal conditions for cell growth and productivity
  • Support setting automated sampling (integrating the process analytical instruments at-line) and integrating the upstream and downstream towards a continuous manufacturing process.
  • ​Generates experimental results and reviews respective scientific documentation
  • ​Is responsible for ensuring that studies are scientifically sound and in line with current regulatory guidance and expectations
  • ​Helps with ensuring lab procedures are adhered to and supports safety assessments
  • ​Design, develop, and implement automated systems to optimize upstream bioprocessing workflows.
  • Collaborate with cross-functional teams to understand process requirements and translate them into efficient automation solutions.
  • Work in close collaboration with IT/OT/Network Infrastructure and Security Teams to ensure a reliable and secure automated manufacturing environment
  • Support updates to and maintenance of data historian systems 
  • Complying with the required relevant Lonza training
  • Perform other duties as assigned

Key requirements:

  • EngD/PhD/MSc/Meng/ Field of Study: Bioprocessing / Chemical Engineering /Biotechnology or similar field
  • In depth knowledge in lab-scale bioreactor control and upstream process development for mammalian cells with 4-5 years of experience.
  • Experience with mechanistic modelling for CHO cell bioprocessing
  • A strong background in mammalian cell culture
  • Knowledge of perfusion techniques and know how to develop new manufacturing processes to produce next generation antibodies.
  • Familiarity with PAT (Process Analytical Technology) tools and analytical techniques (Tridex, Octet) are a plus.
  • Demonstrated innovative skills and experience with leading complex technology projects.
  • High level of communication and presentation skills.

Every day, Lonza’s products and services have a positive impact on millions of people. For us, this is not only a great privilege, but also a great responsibility. How we achieve our business results is just as important as the achievements themselves. At Lonza, we respect and protect our people and our environment. Any success we achieve is no success at all if not achieved ethically.

People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfaction that comes with improving lives all around the world. The satisfaction that comes with making a meaningful difference.

Reference: R57839
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