Advanced expression options for your evolving needs
Developing drugs that depend on a mammalian or microbial process poses unique challenges. The challenge increases when you need to move to cGMP to scale and commercialize new products. To accelerate production, developers need efficient and regulatory-compliant expression systems that scale quickly and reproducibly to meet future needs. With our portfolio of mammalian and microbial expression platforms and expertise, we can help you develop robust processes to equip you for ultimate commercial success.
Our portfolio includes:
- GS Gene Expression System®
- GS piggyBac® transposon technology
- GS Discovery™ transient expression platform
- XS Technologies®
- bYlok® bispecific engineering technology
- Viral vector expression technologies - for AAV production
Lonza in Your Lab™ provides flexibility to either take our technologies into your lab under license, or let Lonza do it for you, at any stage in the process.
Lonza technology platforms available to license include the GS Gene Expression System® mammalian platform including GS piggyBac®, the XS Technologies® microbial platform, and HEK293 cells plus patented vector technologies for AAV production.
Proprietary technology and expertise are at the core of our expression platforms.
The gold standard for fast-track protein expression
Developing protein drugs that depend upon a mammalian or microbial process poses unique challenges that increase as you move from development to commercial scale. To accelerate production, developers need established, efficient and regulatory-compliant expression systems that scale quickly and reproducibly to meet future needs. With our portfolio of mammalian and microbial expression platforms and expertise, we can help you develop such robust processes.
Mammalian protein expression platform
Access our GS Gene Expression System®
GS Gene Expression System® supports the optimal expression and production of monoclonal antibodies, complex proteins and next-generation biologics.
- The complete system includes host cell lines, vectors, access to optimized media and feeds, and process expertise
- GS Xceed® is the industry-recognized host cell line for stable high titers and productivity
- GS piggyBac® transposon technology is now part of the system that can help to overcome the challenge of complex protein expression
- POTELLIGENT® CHOK1SV® host cell line with glycosylation engineering enables the production of recombinant antibodies with enhanced ADCC activity
- GS Discovery™ is a new platform for high titer transient expression
Microbial protein expression platform
Access our XS Technologies® platform
Our XS Technologies® platform includes Pichia pastoris and Escherichia coli expression systems. With a selection of microbial multi-host systems, you can address a diverse range of molecules.
- XS® Pichia Expression System is the best in class for complex, non-glycosylated protein production
- XS® E.coli is one of the most trusted and established organisms for the expression of simple to moderately complex biologics
Redefine your bispecific antibody design engineering challenges with our bYlok™ technology
Solve heavy-light chain mispairing whilst retaining closer-to-nature antibody structure and standard downstream purification with bYlok ® technology.
Access our proprietary technologies supporting viral vector production for cell and gene therapy applications
- Our clonal HEK293 suspension cell line has full traceability and is proven for scalable AAV production
- Our rep/cap and helper plasmids have been developed to support enhanced AAV productivity
- Same tools as used by our services business
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