High Performing Production Host Cell Line and Plasmids
At the heart of our robust processes is our AAV Transient Expression platform. Lonza’s proprietary 5B8 Production Host Cell Line and AAV Production Plasmids were developed based on our experience of the needs of developers of gene therapies. The 5B8 cell line is a HEK293 suspension host cell line, selected and developed at Lonza for high AAV productivity. AAV productivity is boosted by a combination of Lonza’s pHelper plasmid and promoter designed to balance expression of your Rep/Cap proteins across multiple AAV serotypes and genes of interest (GOIs). The 5B8 cell line is cultured in animal-component-free conditions and has demonstrated scalability for AAV production. Established research and cGMP cell banks are available for customer projects. The 5B8 cell line and know-how for production of Lonza’s pHelper plasmid and Rep/Cap promoter are available to license for use in your laboratory or production facility.
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5B8 Production Host Cell Line
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AAV Production Plasmids
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1 Lonza in-house data, comparison to standard commercially available plasmids.
Improve your AAV manufacturing process
To bring our platform to your laboratory, you can license our AAV platform components by emailing VVET@lonza.com
Learn more about our end-to-end cell & gene therapy services.