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Showing 1‐28 of 201
Article
10 min read
Streamlining early phase drug development with continuous flow technologies
As small molecule complexity increases, early-stage development faces new challenges that demand innovative solutions. At Lonza Advanced Synthesis the continuous flow process is integrated into early phase development, allowing for optimization of chemica...
White paper
15 min read
Navigating the development of dry powder for inhalation
Interest in pulmonary/nasal routes for local delivery has significantly increased over the last decade owing to challenges faced in the delivery of molecules with poor solubility, systemic side effects, or new modalities such as biologics. This increasing...
White paper
5 min read
Innovations in linking rational design and material-sparing strategies for enabled intermediates and their drug products
Did you catch our insightful webinar on Linking rational design and material-sparing strategies for enabled intermediates and their drug products? If not, or if you're looking for a concise recap of the key discussions, our new executive summary paper is ...
Webinar (on-demand)
End-to-end regulatory CDMO solutions: development, manufacturing, and approval
Navigating the journey from drug development to market can feel like a maze, with each step presenting unique regulatory hurdles. That's why we hosted our insightful webinar, "End-to-end regulatory CDMO solutions: development, manufacturing, and approval,...
White paper
4 min read
Seamless commercial tech transfers in OSD manufacturing
Remember our insightful webinar on Commercial tech transfers in OSD manufacturing? If you missed it, or want a short recap of the key takeaways, our comprehensive executive summary paper is now available. This paper distills the essential discussions and ...
Webinar (on-demand)
Commercial Tech Transfers in OSD Manufacturing
This webinar explores the critical aspects of manufacturing commercial tech transfers for the manufacture of oral solid dosage (OSD) products. It provides insights into the progression of process validation for existing commercial products, ensuring consi...
White paper
5 min read
The Role of Excipients in Inhaled Biologics
The field of inhaled biologics is rapidly expanding, with both dry and liquid formulations of proteins, peptides, and nucleic acids gaining traction in clinical and commercial applications. Excipients are vital for ensuring the stability, safety, and eff...
Webinar (on-demand)
55 min read
De-Risking Early Phase Micronization with Integrated Solid Form Selection
Achieving the right particle size for respiratory drug delivery is crucial, and jet milling is a key technique. But how do you choose the right API solid form (salt, cocrystal, or solvate) for successful micronization and high yields? This webinar o...
Article
5 min read
Accelerating Drug Development with Precision Powder Micro-Dosing
Drive innovation in early-stage drug development with precision powder micro-dosing.
R&D Blog post
3 min read
Delivering a consistently excellent service with advanced process technologies
As a chemical engineer, it’s perhaps unsurprising that I find it immensely satisfying to use technology to solve problems. Over the past 20 years, I have built my career around finding better processes and techniques for pharmaceutical manufacturing by it...
Webinar (on-demand)
60 min read
Accelerating Clinical Development: Modern Tools in Process Chemistry
This webinar explores how Lonza leverages High-Throughput Experimentation (HTE) and a model-based approach to enhance process development in early-phase projects. Designed to address the unique challenges faced by early-phase customers, the session will ...
White paper
15 min read
Exploring the Need for Dose-Flexible Manufacturing
Bringing a new drug to market is a complex journey, often involving various dosage forms throughout clinical development. From initial discovery to final product, the needs can shift dramatically. For example, pediatric and oncology medicines often requir...
Webinar (on-demand)
Innovative AI-Driven Solutions to Address the Growing Complexity of APIs
Developing innovative medicines often involves intricate small-molecule APIs with lengthy synthetic routes. This complexity can significantly delay preclinical development and create challenges for supply chains. At Lonza Small Molecules, we've developed ...
White paper
Unlocking the Potential of Carrier-Based Formulations: A Process Optimization Guide
Carrier-based formulations are commonly used in drug delivery systems, particularly in inhalation therapies. These formulations involve dispersing active pharmaceutical ingredients (APIs) onto carrier particles, facilitating their delivery to the lungs. ...
Video
30 min read
Small Molecule API & HPAPI Development Capacity
This video presents Lonza's capabilities, facility locations, and timelines to assist biopharma companies in identifying suitable partners for their development and manufacturing needs. Lonza is known for its expertise in particle engineering and has mult...
Webinar (on-demand)
Linking Rational Design and Material-Sparing Strategies for Enabled Intermediates and Their Drug Products
The rapid development of enabled forms and formulations is crucial for tackling the challenges posed by poorly soluble molecules. In this webinar, we delve into the importance of identifying unique risks to oral bioavailability and explore effective solut...
Webinar (on-demand)
50 min read
Excipients for Respiratory Delivery of Biologics
Local administration of biologic Active Pharmaceutical Ingredients to the lung via inhalation has grown in recent years. Dry and liquid dosage forms of protein-, peptide-, and nucleic acid-based therapies have been developed for respiratory delivery in cl...
White paper
10 min read
Optimizing Spray-Dried Dispersion Processes Through Risk-Based Development
This executive summary explores a risk-based approach to process qualification, demonstrating how small-scale experiments can mitigate risk and reduce material consumption. It also delves into product design considerations and how a risk-based approach ca...
White paper
15 min read
Micro-dosing: Navigating the Path from Development to Commercialization with Powder-in-Capsule Technology
Microdosing, a technique involving the administration of precise, minimal drug doses, can significantly accelerate the drug development process. By directly encapsulating drug substances into capsules, the powder-in-capsule (PIC) approach streamlines ear...
White paper
15 min read
Dry Powder Vaccines to Improve Global Access and Pandemic Response
Many vaccines require cold chain storage and distribution, limiting their accessibility in resource-poor regions. Dry powder formulations offer a promising solution by eliminating the need for refrigeration. This technology can significantly improve globa...
White paper
From Technology Selection to Final Drug Product
Many new active pharmaceutical ingredients (APIs) suffer from poor gastro-intestinal solubility in their crystalline form. This low solubility can prevent the drug from reaching its effective dose and lead to a significant pill burden for the patient, dri...
Podcast
2 min read
A View On Emerging Trends in Pharmaceutical Manufacturing, live from CPHI Milan (S04 E01)
In this first episode of A View On’s fourth season, recorded at the Convention on Pharmaceutical Ingredients (CPhI) in Milan, we dive into the latest innovations and challenges shaping the pharmaceutical landscape.
Webinar (on-demand)
Enabled Form Selection for Oral Drug Products Using a Combination of In-Silico Modeling and In-Vitro Measurements
Many new drug candidates face the hurdle of low aqueous solubility, hindering their absorption and progression to clinical trials. PBPK modeling, coupled with strategic in vitro measurements, offers a rapid and cost-effective approach to identify potentia...
Webinar (on-demand)
Beyond Jet Milling: A Deep Dive into Carrier-Based Formulation and Process Optimization
This webinar will look at the requirements for pulmonary delivery via carrier-based inhaled powder formulations, and how jet milling can be used to manufacture effective and stable materials for these formulations. It will also look at how it can be integ...
Webinar (on-demand)
Flexible-Dose Development Strategies for Today's Clinical Landscape
This on-demand webinar explores the importance of dose-flexible manufacturing strategies in modern drug development. With a growing emphasis on early clinical studies, especially in pediatric and oncology treatments, flexible dosing is becoming crucial. H...
Webinar (on-demand)
Innovative AI-Driven Solutions to Address the Growing Complexity of APIs
The complexity of small molecule active pharmaceutical ingredients (APIs) is rising, bringing longer syntheses that challenge innovators' timely readiness for the Clinic.[1] Longer synthetic pathways make it more difficult for process chemists to achieve ...
e-book
15 min read
Navigating Commercial Drug Development Technologies for Formulation Excellence
Our Small Molecule division is focused on leveraging its technologies and expertise to address solubility challenges and support drug development programs through commercialization. Download our e-book to learn about the importance of patient-centric form...
White paper
20 min read
Powering Drug Development with Advanced Retrosynthetic Analysis Tools
As small molecule APIs become increasingly complex, longer synthetic pathways present new challenges for process chemists. Drug developers are turning to evolving tools to find reliable and efficient synthesis routes to produce small molecule APIs. This w...