Biotherapeutic programs demand expression systems that perform reliably from the very first step. In this session, we explore how refined DNA construct architecture can influence development outcomes long before upstream optimisation begins. By examining key genetic control elements and their interaction with CHO host biology, we highlight how thoughtful vector engineering can strengthen production robustness, consistency, and long‑term stability.
The webinar describes the GS Xceed® gene expression system, GS piggyBac® transposon technology and the development of the GSquad® Pro vector system, Lonza’s next‑generation DNA vector framework, together with LHP‑1, its enhanced transcriptional promoter designed to support stronger and more balanced gene expression. You’ll also gain an inside look at how Lonza is generating advanced datasets in CHO gene regulation, data that is guiding the next wave of vector innovation and enabling more predictable manufacturing performance.
What You’ll Learn:
- How core vector architecture influences CHO cell productivity and stability
- The scientific principles behind the GSquad® Pro vector system and its new promoter design
- How Lonza’s data‑driven expression‑control insights are shaping future vector engineering strategies
