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  • GS Xceed® Gene Expression System

Optimal Therapeutic Protein Expression with GS Gene Expression System®

Contact us

The GS Xceed® Expression System offers you a robust, fully integrated and scalable mammalian system that can express a diverse range of biologic drugs.

It includes:

  • Vectors
  • Host cell lines
  • Access to optimized media and feed
Optimize your therapeutic protein expression with the GS Gene Expression System®

Combining our advanced proprietary technology with our unparalleled expertise, the GS® expression platform can help you optimize your therapeutic protein expression. With the ability to rapidly and reliably generate high-producing cell lines, we can support the optimal expression of monoclonal antibodies and next-generation biologics, helping reduce your time to market.

Download the brochure

Access a range of mammalian protein expression technologies

Benefit from access to our proven and scalable CHO based gene expression system to create a diverse range of biologic drugs. As market demand continues to rise for more potent and effective therapeutics, drug developers are identifying novel disease targets and biological mechanisms for new medicines. As a result, biologic pipelines are developing from standard antibody formats to next-generation biologics.

Proprietary technology and expertise are at the core of our expression platforms. Combined with our experience, it makes us the ideal partner to provide you with a robust and versatile expression system to optimize your production.

Take our advanced technologies in your laboratory under a license or rely on Lonza to do it for you.

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From our clients
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This powerful GS platform enabled us to fast-track CMC development from stable cell line generation to non-GMP Tox material supply to GMP clinical manufacturing.

— Dr. Feng Hui, Chief Operation Officer, Junshi Biosciences, China. July 2020

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I just wanted to send a specific note of thanks for your early support in getting us the Xceed system – it was truly a differentiator for the program.

— Prof. Trent Munro, Program Director, The University of Queensland, Australia. June 2020

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Integrating GS piggyBac® transposon technology to GS Xceed® results in higher bsAb expression, and offers benefits for bioprocessing for low expressing proteins, helping to generate high performing pools.

— Dr. Jizu Yi, Senior Vice President, YZY Biopharma, China. June 2021

company testimonial logos 
We have successfully expressed and produced a variety of recombinant bispecific antibodies and viral proteins by Lonza's GS Xceed expression system. The viral antigens expressed by the GS Xceed® system show superior immunogenicity and the glycosylation type covers the kinds of viral proteins already available quite well. 

— Jian Kong, CEO, Luzhu Biotech. Apr 2022

company testimonial logos 
... GSv9™ Media and Feeds resulted in ~50% more antibody production. Its preparation demonstrated to be less time-consuming and labor intensive. The GSv9™ Media demonstrated a higher potential for prolonging cell culture for additional day(s).

— Dr. Faraz Harsini, Scientist, Xbiotech Inc, USA. Sep 2020

company testimonial logos 
..having access to the Lonza system during the pandemic really empowered our work. Lonza has spent years developing the GS SYSTEM to get it to where it is today, and the combination of the GS knockout cell line and cell culture platform result in a robust upstream platform. The GS XCEED expression system brought great benefits to our project because it allowed us to move fast – speed was clearly crucial at the start of a public health crisis.

— Prof. Trent Munro, Program Director, The University of Queensland, Australia. Dec 2021

Latest research using GS System®

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Services enabled by this technology

Rapid Host Screen and Early Protein Expression
Select the optimal expression system for your biotherapeutic protein production with our Rapid Host...
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Non-GMP Manufacture: Light Path™ Discovery
Our Light Path™ Discovery Protein Production Services provide milligram to low gram quantities of...
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Mammalian Cell Line Development
Benefit from our flexible approach to cell line development matching your project’s priorities in...
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Biologics

Knowledge Center

Knowledge Center
Webinar on-demand
Webinar (on-demand)
Tools for Developing Successful Biologics CHOK1SV GS-KO® Cell Line
CHOK1SV GS-KO® is available as part of the GS Xceed® Expression System, which provides a scalable...
Technical/Service brief
Tools for Developing Successful Biologics - Vectors for the GS Gene Expression System®
We have developed a series of advanced vector systems with applications in producing standard...
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Becoming a Champion Go Player
Although antibodies, at the time of writing, still dominate the clinic, there is a definite shift in...
Article
When One Size Doesn't Fit All
Biologic pipelines are evolving towards more complex and difficult to express formats. Bispecific...
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Challenges of Manufacturing the Expanding Range of BiMultispecific Modalities
The pharmaceutical industry is increasingly focused on the development of next-generation drug...
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