PATENT RIGHTS (LONZA)


Lonza Ref. No. LBP1001 / LP3062


Title: Methods for Expressing Recombinant Protein in CHO Cells
Subject Matter: Use of mCMV promoter for expression, or
Use of mCMV promoter for enhancing Transfection Rate
Registered Owner: Lonza Biologics plc
Territory Filing Date Patent No. Expiry Date
Australia21.07.03200325143421.07.23
Australia19.02.09200920066521.07.23
Canada21.07.03248901621.07.23
Canada21.07.03267280921.07.23
China21.07.030381691421.07.23
ǂEurope21.07.03152532021.07.23
Hong Kong21.07.03108159521.07.23
India21.07.0322923321.07.23
Japan 21.07.03443053521.07.23
Japan21.07.03520969321.07.23
Japan21.07.03550240621.07.23
Singapore21.07.0310971521.07.23
South Korea21.07.0397609821.07.23
USA*21.12.077,932,08707.03.24

ǂvalidated in: Austria, Belgium, Bulgaria, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Luxembourg, Netherlands, Portugal, Romania, Slovenia, Slovakia, Spain, Sweden, Switzerland, Turkey, United Kingdom
* with patent term adjustment of 230 days


Lonza Ref. No. LBP1008 / LP3069


Title: Mammalian expression vector comprising mCMV promoter and first intron of hCMV major immediate early gene
Registered Owner: Lonza Biologics plc
Territory Filing Date Patent No. Expiry Date
Australia22.04.06200623719320.04.26
Hong Kong20.04.06111973720.04.26
India20.04.0625724620.04.26

Lonza Ref. No. LBP1009 / LP3070


Title: High level expression of recombinant antibody in a mammalian host cell
Subject Matter: Selective codon adaption / antibody expression
Registered Owner: Lonza Biologics plc
Territory Filing Date Patent No. Expiry Date
Australia19.05.06200624908719.05.26
China19.05.06200680017582.819.05.26
Europe19.05.06191539419.05.26
Hong Kong19.05.06112005019.05.26
India19.05.0626324219.05.26
Israel19.05.0618710019.05.26
Japan19.05.06499170519.05.26
South Korea19.05.06127382919.05.26

PATENT RIGHTS (THIRD PARTY)


Title: Engineering of I-CreI meganuclease variants cleaving a glutamine synthetase gene target sequence and uses for genome therapy
Subject Matter: Engineered meganuclease variants to knock out GS gene
Registered Owner: Cellectis
Territory Filing Date Appl. No. Patent No. Expiry Date
ǂEurope08.09.2008 2352821 08.09.2028
USA*27.05.2011 9,273,29613.03.2031

ǂ validated in Switzerland, Germany, France and United Kingdom
* with patent term adjustment of 916 days


Subject Matter: Rational-designed Meganucleases with Altered Sequence Specificity and DNA-binding Afffinity
Registered Owner: Precision BioSciences (Duke University)
Territory Filing Date Appl. No. Patent No. Expiry Date
Australia18.10.06 200630466818.10.26
Canada18.10.06 262626218.10.26
Canada18.10.063055968Pending18.10.26
Europe18.10.06 194576218.10.26
Europe18.10.06 235722618.10.26
Europe18.10.06 236024418.10.26
Europe18.10.06 248475818.10.26
Europe18.10.06 265036518.10.26
Europe18.10.06 265036618.10.26
Europe18.10.06 266244218.10.26
Europe18.10.06 262879418.10.26
Europe18.10.06 324640318.10.26
Japan18.10.06 593729218.10.26
Japan18.10.06 614843718.10.26
Japan18.10.06 605061118.10.26
USA*18.10.06 8,021,86719.02.29
USA26.09.11 8,143,01518.10.26
USA27.09.11 8,148,09818.10.26
USA27.09.11 8,163,51418.10.26
USA26.09.11 8,119,36118.10.26
USA26.04.12 8,304,22218.10.26
USA25.06.12 8,377,67418.10.26
USA01.08.1715/666,425Pending18.10.26 (w/o ext)

* with patent term adjustment of 845 days


Title: Expression Vectors Comprising the mCMV 1E2 Promoter
Subject Matter: Use of mCMV promoter for expression, or
Use of mCMV promoter for enhancing Transfection Rate
Registered Owner: Merck Serono SA
Territory Filing Date Appl. No. Patent No. Expiry Date
Australia10.03.04200421991710.03.24
Canada10.03.042,516,15710.03.24
China10.03.0410042931510.03.24
ǂEurope10.03.04160177610.03.24
Hong Kong14.07.06108576610.03.24
India10.03.0424438210.03.24
Israel10.03.0417075410.03.24
Japan10.03.04517103310.03.24
Japan10.03.04584820210.03.24
Mexico10.03.0490301610.03.24
Norway10.03.0433381810.03.24
Russian Federation10.03.0401009610.03.24
Singapore10.03.0411440710.03.24
South Africa10.03.042005/0640010.03.24
South Korea10.03.041011-8013910.03.24
Ukraine10.03.048813810.03.24
USA*10.03.047,824,90730.05.26
USA**31.08.109,051,58228.02.25

* with patent term adjustment of 811 days
** with patent term adjustment of 355 days
ǂ includes: Albania, Austria, Belgium, Bosnia-Herzegovina, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Latvia, Lithuania, Luxembourg, Macedonia, Monaco, Netherlands, Norway, Poland, Portugal, Romania, Serbia, Slovenia, Slovakia, Spain, Sweden, Switzerland, Turkey, United Kingdom


Title: Methods and compositions for transposition using minimal segments of the eukaryotic transformation vector piggyBac
Registered Owner: University of Notre Dame du Lac
Territory Filing Date Appl. No. Patent No. Expiry Date
USA*30.10.01 6,962,81025.10.22
USA**19.04.04 7,105,34326.12.21
USA***19.06.06 10,087,46325.10.22
USA19.03.1916/111,032Pending30.10.21(w/o ext)

* with patent term adjustment of 360 days
** with patent term adjustment of 57 days
*** with patent term adjustment of 373 days and terminal disclaimer
ǂ validated in Switzerland, Germany, France, United Kingdom, and Ireland


Title: Hyperactive piggyBac Transposases
Registered Owner: Poseida Therapeutics, Inc.
Territory Filing Date Appl. No. Patent No. Expiry Date
ǂEurope25.02.10 240136725.02.30
Europe25.02.1016200960.9Pending25.02.30
USA*25.02.10 8,399,64310.04.30
USA**22.02.13 9,546,38227.03.31
USA28.07.16 10,287,55925.02.30
USA20.12.17 10,131,88525.02.30
USA19.03.1916/358,609Pending25.02.30 (w/o ext)

ǂ validated in Switzerland, Germany, France, United Kingdom, and Ireland
* with patent term adjustment of 44 days
** with patent term adjustment of 395 days


Title: Methods and Compositions For Seamless Cloning Of Nucleic Acid Molecules
Subject Matter: Cloning or subcloning one or more nucleic acid molecules comprising one or more type IIs restriction enzyme recognition sites (multiple gene assembly).
Registered Owner: Life Technologies Corporation
Territory Filing Date Patent No. Expiry Date
USA21.02.128,338,09109.08.24

Title: System and Method of Modular Cloning
Subject Matter: Cloning system for producing a nucleic acid construct of interest using type IIs restriction endonucleases.
Registered Owner: Icon Genetics GmbH
Territory Filing Date Appl. No. Patent No. Expiry Date
Europe06.09.11 258033206.09.31
Europe25.11.16  315941206.09.31
USA27.06.1715/634,803Pending06.09.31 (w/o ext)