The purpose of this work is to introduce solvent-assisted secondary drying, a method used to accelerate the residual solvent removal from spray-dried materials. Spray drying is used to manufacture amorphous solid dispersions, which enhance the bioavailability of active pharmaceutical ingredients (APIs) with low aqueous solubility. In the spray drying process, API and excipients are co-dissolved in a volatile organic solvent, atomized into droplets through a nozzle, and introduced to a drying chamber containing heated nitrogen gas. The product dries rapidly to form a powder, but small amounts of residual solvent remain in the product and must be removed in a secondary drying process. For some spray-dried materials, secondary drying by traditional techniques can take days and requires balancing stability risks with process time.  To learn more, please download our publication.
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