Development of robust oral drug products requires biopredictive in vitro dissolution methods to evaluate how drug formulation and GI physiology impact bioperformance. Knowledge of the in vivo problem statement and rate-determining step to absorption can aid in selecting and designing effective dissolution methods.
Amorphous solid dispersions (ASDs) are an important formulation strategy for improving oral absorption of poorly water-soluble drugs. To develop ASD drug products that perform well in vivo, pharmaceutical scientists must combine knowledge of key drug, polymer and gastrointestinal properties with in vitro and in silico test methods. This talk describes use of in vitro and in silico tools to successfully predict performance of an ASD drug product in beagle dogs with low and high gastric pH.
Watch this on-demand presentation to learn more about:
- Key drivers of amorphous solid dispersion bioperformance
- In vitro and in silico testing of acalabrutinib ASD tablets to overcome pH effect