In the webinar "Enabling Technologies to Increase Spray Drying Throughput for Brick Dust Compounds," Lonza's experts discussed three enabling technologies designed to improve drug solubility in organic solvents for spray drying as well as case studies detailing the process for each one. These methods include heating a drug slurry to a temperature below the solvent’s boiling point, which increases its solubility; using an in-line heat exchanger to rapidly increase the temperature of the solution above the boiling point immediately before atomization, dissolving the drug at a higher concentration (known as temperature shift); and using volatile processing aids, with no need for heating or other changes to the normal spray drying process. Not only can these methods increase solubility in compounds with poor solubility, but they can also increase throughput, ultimately reducing solvent consumption, cycle times, and costs. The following Q&A session was held after this webinar, where Lyon and Adam addressed attendees’ questions about the details of the methods and case studies.


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