The Lonza Cocoon® Platform uniquely addresses the challenges of automated cell therapy manufacturing by enabling at-line integration of a variety of complementary systems such as Process Analytical Technologies (PAT) and electroporation. The integration of automated PAT and genetic modification processes into cell therapy manufacturing workflows enables greater flexibility for process design and translation.
This advanced cell therapy manufacturing platform provides a controlled cell processing system that enables functionally closed and automated delivery of cell culture samples to at-line connected instrumentation, improving high process efficiency, and analytical reliability. Monitoring critical process parameters (CPP) for data driven decision making is essential for process optimization and cell product consistency and often becomes a cost driving feature in cell therapy manufacturing. There is a significant demand for solutions that offer closed, automated CPP monitoring, however, many bioreactor platforms lack the required versatility, making the integration of PAT difficult.