Proven multiparticulate drug delivery system technologies (MPs)
MP formulations continue to grow in application due to their inherent advantages, including the greater flexibility they offer compared with monolithic formats. They:
- Offer a wide range of flexibility in drug-release profile for single or multiple drug combinations and enable formulation as modified release, immediate release, bioavailability-enhanced, and/or taste-masked dosage forms
- Provide predictable and consistent GI transit and lower chances of undesirable events associated with tablets (e.g. dose dumping)
- Can facilitate ease of swallowing, an attribute increasingly important in targeted medications for pediatric and geriatric populations
- Can be formulated into encapsulated, tablet or sachet formats. The selection of a specific MP technology is typically dependent upon the API characteristics and target product profile.
Our range of multiparticulate technologies
MP Range | Process | Amorphous / Solubilized Form | Taste Making | Immediate Release | Delayed / Burst | Controlled Release | ||
---|---|---|---|---|---|---|---|---|
Fluid Layered MP's | pH trigger | Fluid bed | ||||||
Time trigger | Fluid bed | |||||||
Diffusion control | Fluid bed | |||||||
Matrix MP's | Lipid matrix | Melt-spray congeal | Plus coating if needed |
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IR and MR granules | Wet / Dry granulation | Coating | ||||||
Mini-tablets | Tableting | Coating |