MemreePlus™ Studies Provide Evidence of Benefit to Memory, Mood and Cognitive Function in Elderly
Basel, Switzerland, 1 December 2014 – Lonza today announces the publication of the results of two early pilot studies performed using soy lecithin-derived phosphatidylserine (PS) and phosphatidic acid (PA), which appeared in the November issue of Advances in Therapy. The results of both studies provide evidence suggesting a combination of PS and PA – as in Lonza’s proprietary MemreePlus™ ingredient – can support memory and cognitive function, which is especially apparent in those who have developed cognition deficiencies. The publication of the results can be found here: http://link.springer.com/article/10.1007%2Fs12325-014-0165-1
Since 2011 Lonza and PS supplier Lipogen LTD have worked together under an exclusive distribution agreement to offer Lipogen’s PS products as Lonza MemreePS™ ingredient. The two previously unpublished, early pilot studies funded by Lipogen used a combination of 100 mg PS and 80 mg PA three times per day.
The first study, a three-month, double-blind, placebo-controlled study with PS and PA in 72 functioning, non-depressive elderly with memory problems, demonstrated a statistically significant positive influence of PS and PA on memory, mood and cognition in pre-post comparison.
The second study, a two-month, randomized, double-blind, placebo-controlled study with PS and PA in 96 patients with Alzheimer’s disease, demonstrated a significant stabilizing effect of PS and PA on daily functioning, when comparing both groups. There also were some improvements in emotional state and self-reported general condition in the PS + PA group; no negative side effects were observed.
At the conclusion of the studies, the combination of PS and PA demonstrated a positive influence on memory, mood and cognition among elderly test subjects with memory problems. Therefore, the data encourage long-term studies with PS and PA in Alzheimer’s patients and other elderly with memory or cognition problems.
“The sum of these studies validates MemreePlus™ ingredient, Lonza’s proprietary blend of soy-based PS and PA, for formulation into nutritional supplements as a memory and cognitive support ingredient,” said Matthias Ruesing, PhD, Global Product Manager for the Memree™ product line at Lonza. “We will continue to further investigate the benefits of MemreePS™ and MemreePlus™ PS+PA, alongside our continued research being conducted with our entire nutrition ingredients portfolio.”
Earlier this year another published study confirmed that supplementation with MemreePlus™ ingredient can support a normal stress response in chronically stressed male adults. Those findings were published in Lipids in Health and Disease and can be found here: http://www.lipidworld.com/content/13/1/121/abstract.