An increasing number of compounds in the drug development pipeline (>70%) are poorly soluble in water, and also in organic solvents. Spray drying is commonly used to increase bioavailability, but these 'brick dust'; compounds require additional innovative steps if spray drying is to yield a commercially attractive process.
In this webinar, we discuss three enabling technologies designed to improve drug solubility in organic solvents for spray drying. The significant increases in solubility provided by these three technologies can be enabling for compounds with poor solubility. In addition, the increased throughput has the additional benefit of reducing solvent consumption, cycle times, and costs.
Key Learning Objectives:
- Learn three technologies that increase organic solvent solubility, and how to implement them in spray drying processes
- Define the advantages and risks of each technology, and understand selection criteria for individual active pharmaceutical ingredients
- Determine the impact of these processes on throughput, and how they can save time and money