Dissolution tends to be the rate-limiting step in oral delivery of poorly soluble, highly permeable solid dosage forms. Drug properties that can be rate-controlling in the dissolution process are intrinsic solubility, pKa, particle size and polydispersity, particle shape, and acid/base character. In addition to drug properties, physiological parameters such as the buffer type and concentration, bulk pH, fluid volume, and hydrodynamic conditions play a role in drug dissolution both under in vivo and in vitro conditions. Understanding the critical factors in drug dissolution under in vitro and in vivo conditions facilitates the development of in vitro predictive dissolution methodologies that can simulate the in vivo drug dissolution. To learn more, download our poster.
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