Hot melt extrusion (HME) is a leading approach to producing amorphous solid dispersions to increase solubility and bioavailability of promising drug compounds. HME technology offers numerous advantages, including well-defined process understanding, small equipment footprint, efficient (continuous) operation, and ready scalability.

This technical brief describes Lonza's depth of experience with HME formulation and processing and its broad production capabilities in this important technology area.

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