Inclusion Bodies – Mother Nature's Help or Hindrance?

Producing insoluble protein in inclusion bodies can and often is more economical from a bioprocessing perspective.  We explain the pros and cons of soluble and insoluble processes, share our experience with isolating, solubilizing and properly re-folding, and argue that the right approach to insoluble processes can not only be viable at scale but can offer great opportunities for yield improvement versus soluble production.