In recent years the number of biotherapeutic molecules requiring more complex assemblies has greatly increased. Typically, these multi-chain molecules are no longer compatible with platform approaches and require a more flexible and agile approach to early developability and method development. Lonza have developed a Toolbox approach using in silico tools, vector design/screening and analytical method development to de-risk process development and manufacturing. This toolbox approach allows us to screen for titre and product assembly at an early stage of development.

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