Optimizing Bispecific Antibody Clonal Cell Selection with High-Throughput Analytics

It is possible to manufacture monoclonal antibodies using traditional methods, but the challenges inherent in bispecific antibodies such as low titer, mismatched chains, unwanted fragments and higher aggregation levels require a heightened analytical focus on clonal cell selection. Here, Stuart Jamieson and Alice Harrison discuss high-throughput analytical strategies that enable right-first-time selection of the optimal clone to take through to clinical manufacture.