Bispecific antibodies (bsAbs) can simultaneously bind two different antigens via distinct antigen binding sites, enabling a variety of benefits.

However, bsAbs can be challenging to generate. One of the most commonly reported issues with bsAb production concerns heavy chain (HC) and light chain (LC) mispairing.

In this technical note, we describe how Lonza’s bYlok® technology ensures high levels of accurate HC-LC pairing without detriment to critical quality attributes such as titer, binding affinity, stability, and immunogenicity.

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