Modeling the Impact of Amorphous Drug-Polymer Colloids on the Absorption of Poorly Water Soluble Drugs

Formulation of amorphous solid dispersions, as means to improve absorption for poorly water soluble drugs, has proven to be a reliable and effective approach. In assessing how these formulations perform in vivo, it has been observed that they can dissolve into multiple species in biorelevant media. These species can be supersaturated free drug, drug partitioned into bile salt micelles and amorphous drug-polymer colloids, as well as precipitated amorphous or crystalline drug. Here, the impact of amorphous drug-polymer colloids on the absorption of several water insoluble drugs is modeled based on a modified permeability equation that takes these nano-sized colloids into account. The model simulations are compared to three literature in vivo studies, as well as the simulation for those using the standard permeability calculation. To learn more, download our poster.