Substantial progress has been made over the last decade in developing Raman concentration models which generalize well across cell lines and products. This progress has allowed the technology to be practically used to continuously monitor and control key nutrient concentrations in bioreactor processes.
In this article, Lonza’s Brandon Downey, Thaddaeus Webster and Carrie Mason explore the role of Raman spectroscopy in generating automated, robust and lower cost manufacture of biopharmaceutical products.