Practical Approach to Modeling the Impact of Amorphous Drug Nanoparticles on the Oral Absorption of Poorly Soluble Drugs

This paper describes a study that evaluated the mechanisms by which drug nanoparticles may enhance bioavailability by acting as  "shuttles" for drug across the unstirred water layer (UWL). Using three case studies, the nanomodified permeability method proved to be a suitable, fit-for-purpose in silico approach for evaluating or predicting oral absorption of poorly soluble, UWL-limited drugs from formulations that produce a significant number of amorphous drug nanoparticles. To learn more, please read our publication.