Principal Scientist mRNA (m/f/d)

Netherlands, Geleen

Today, Lonza is a global leader in life sciences operating across three continents. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that’s the kind of work we want to be part of.

We are currently looking for a Principal Scientist to join our team in Geleen, working on one of Lonza’s key strategic projects. As Principal Scientist you will be a highly experienced professional and a lead scientist in the field of biotech process development, with particular experience in  In Vitro Transcription (IVT), purification techniques associated to biomolecules such as chromatography and tangential flow filtration (TFF). In addition you will possess good knowledge of analytical methods, Design of Experiment (DoE) studies and scale-ups.

Please note that in the early stages of this project there will be a requirement to spend some time in Visp for a short period of time before returning to Geleen.

Key responsibilities:

  • Representation: act as a deputy of the team manager when needed and support the process development management.
  • Leadership: provide strong scientific, technical and regulatory leadership at project level. Lead individual scientists and lab technicians on complex projects.
  • Projects: lead multi-disciplinary matrix teams on complex projects in the area of scientific expertise. Lead problem solving and lessons learned activities.
  • Scientific tasks: design advanced experimental plans and data analysis methods, write and review high quality reports.
  • Customer interactions: develop strong customer relationships.
  • Training: lead training activities in the area of expertise.

Key requirements:

  • Deep Understanding of IVT critical process parameters, reaction optimization and scale-up.
  • Experience in mRNA purification or very broad & deep expert-level experience & understanding of purification of biomolecules.
  • Experience with purification techniques such as chromatography (including affinity, ion exchange hydrophobic interactions, etc.) and tangential flow filtration (TFF).
  • Experience with a wide range of mRNA analytical techniques for large nucleic acid molecules, in particular with analytical assays associated with IVT and purification processes.
  • Implementation of DOE studies & high-throughput screening for IVT and  purification processes.
  • Knowledge of scale-up, technology transfer and GMP manufacturing.
  • Demonstrated ability to efficiently work in a fast paced and fluid environment .

Every day, Lonza’s products and services have a positive impact on millions of people. For us, this is not only a great privilege, but also a great responsibility. How we achieve our business results is just as important as the achievements themselves. At Lonza, we respect and protect our people and our environment. Any success we achieve is no success at all if not achieved ethically.

People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfaction that comes with improving lives all around the world. The satisfaction that comes with making a meaningful difference.

Reference: R43942
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