Senior Principal Scientist - Upstream (Perfusion SuB)

United Kingdom, Slough

Today, Lonza is a global leader in life sciences operating across three continents. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that’s the kind of work we want to be part of.

We are currently looking to recruit a Senior Principal Scientist – Upstream – Perfusion to join our growing Process Development Sciences (PDS) team, a team of subject matter expects with extensive experience within upstream and downstream science and in product characteristics.

As a Senior Principal Scientist – Upstream – perfusion, you will provide SME understanding of perfusion and fed-batch based upstream systems within mammalian expressed mAbs and complex proteins from development lab, through to pilot and into manufacturing.

This is an exciting opportunity to work as a technical expert to deliver strategic vision within an innovative technology at Lonza!


Key responsibilities:

  • Providing proactive scientific technical leadership in the areas of SUB production options for perfusion and fed-batch trains from 10L to 20KL in pilot and GMP settings. 

  • Translating market technology trends into actionable technical plans to upgrade Lonza service offering

  • Delivering strategic vision to influence the network direction within Mammalian protein programs and offering alongside operational and commercial teams.

  • Providing in-depth scientific leadership in matrix environment to support for Proposals and Sales teams to maximize the win rate of Complex Protein proposals for Cell Line Constructions and Drop-In projects

  • Responsible for collaboratively providing scientific support across departments and sites for significant technical challenges

  • Directly contribute to quantitative project risk/benefit analysis and decisions. Participate/lead risk assessments as required 

  • Provide SME input into recommendation and management of software control systems for bioreactor operations

  • Expanding technical program understanding, take part in training of Operations team as required. Mentor/coach existing lab scientists and junior SMEs and lead the implementation of sustainable development & training programs

  • Champion systems improvements by supporting the definition of data sources, collection methods, analysis and definition of key knowledge areas critical to successful next generation development for complex protein projects

  • Maintain knowledge of IP landscape related to SME knowledge

Key requirements:

  • BSC, MsC or PHD life sciences, and relevant experience within biopharma/biotech industry

  • Extensive experience in pre-clinical development, mammalian cell culture development using broad range of single use bioreactors and specifically perfusion bioreactor processes essential

  • Strong technical expertise of process development, and application for upstream techniques to pilot and into manufacturing

  • Extensive knowledge and experience of working within perfusion technology within a development setting as a minimum

  • Experience working with a range of different molecules (mAbs, complex proteins) desirable

  • Strong communication skills with good evidence of stakeholder management, with the ability to lead and collaborate projects

Every day, Lonza’s products and services have a positive impact on millions of people. For us, this is not only a great privilege, but also a great responsibility. How we achieve our business results is just as important as the achievements themselves. At Lonza, we respect and protect our people and our environment. Any success we achieve is no success at all if not achieved ethically.

People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfaction that comes with improving lives all around the world. The satisfaction that comes with making a meaningful difference.

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Reference: R37658