Senior Scientist, Cell Culture Development

Singapore, Tuas Singapore

Today, Lonza is a global leader in life sciences operating across three continents. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that’s the kind of work we want to be part of.

You will be joining the Cell Culture Development team within Development Services at Lonza Singapore. Development Services are responsible for the laboratory-scale development and characterization of manufacturing processes used for the production of novel therapeutic recombinant proteins for Lonza’s global client base. The purpose of this role is to execute mammalian cell line and upstream process development activities and to provide technical expertise to support troubleshooting activities at both laboratory and manufacturing scale. You will be working in a highly dynamic environment where we utilize the latest cutting edge equipment and technologies to exceed our customer’s expectations.

Key responsibilities:

  • To perform hands-on laboratory work in the cell line and upstream process development team contributing to the development of processes suitable for technology transfer to the cGMP manufacturing teams. An understanding of cGMP manufacturing facility constraints and their impact on development activities will be developed.
  • Lead process development and characterization activities by performing supporting laboratory scale studies.
  • Interpret analytical data provided by the analytical team to define subsequent steps.
  • Taking a lead role within a site and global project team to ensure timely delivery of project workstages.
  • Deliver high quality communication to ensure an outstanding customer experience (written reports, teleconferences and face to face meetings).
  • Mammalian cell culture processes include: Cell Line Development (routine cell culture, FACS); Process Development (ambr15 miniaturized bioreactors, 10L laboratory scale bioreactors); Process Characterization (ambr250 miniaturized bioreactors, 10L laboratory scale bioreactors).

Key requirements:

  • Degree/Masters with at least 4-6 years of experience or PhD in a relevant Science field or equivalent with 2-4 years of experience.
  • Substantial practical laboratory experience in mammalian cell line development and/or upstream process development is required.
  • A demonstrated understanding of the theory and application of recombinant protein expression using mammalian cell culture systems and/or bioreactor process development, scale up and technology transfer.
  • Experience of DoE methodologies would be beneficial.
  • Understanding of cGMP regulations.
  • Good problem solving, analytical and teamworking skills.
  • Good communication skills (verbal and written).
  • The role will require weekend working on a rota based system.

Every day, Lonza’s products and services have a positive impact on millions of people. For us, this is not only a great privilege, but also a great responsibility. How we achieve our business results is just as important as the achievements themselves. At Lonza, we respect and protect our people and our environment. Any success we achieve is no success at all if not achieved ethically.

People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfaction that comes with improving lives all around the world. The satisfaction that comes with making a meaningful difference.

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Reference: R34803
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