Lead Scientist - Mammalian cell biology

United Kingdom, Slough

Today, Lonza is a global leader in life sciences operating across three continents. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that’s the kind of work we want to be part of.

We have an opportunity for an experienced cell biologist with extensive knowledge of mammalian cell  cycle,  metabolism,  signaling  pathways/CHO  cell  biology  to  join  our  team  of  experts  in  Cell Culture Media Development as a Lead Scientist. This is a fast-growing team that is purely focused on  innovation  and  a  unique  opportunity  to  help  cell  culture  media  development  projects  in multidisciplinary and dynamic team.

Key responsibilities:

  • Working closely with the Head, Media R&D Slough; plans and prioritizes tasks and assignments in a work program
  • Understand and manipulate GS-CHO cell cycle regulation in vitro to develop cell culture media for producing biologically active proteins, monoclonal antibodies and biosimilars
  • Executes experimental plans, analyse experimental data, writes technical reports
  • Is responsible for ensuring that studies are scientifically sound and in line with current regulatory guidance and expectations
  • Contribute scientific expertise and propose new ideas and product concepts targeting the research market, drawn from scientific literature and personal experience
  • Ensures GLP and EHS regulations are followed
  • Perform other duties as assigned   

Key requirements:

  • PhD with postdoctoral experience or industrial experience
  • Knowledge of CHO cell biology, cell cycle regulation, CHO cell metabolism is highly desirable
  • In-depth knowledge of basic cell biology techniques, i.e., mammalian cell culture, Flow Cytometry, Western blotting, RT-PCR, confocal microscopy etc is highly desirable
  • Experience with high-throughput small scale bioreactors i.e., ambr15, ambr250 is advantageous
  • Good understanding of upstream processes, including fed-batch and perfusion cultures
  • Cell associated analytics experience
  • Knowledgeable of the current best practices for developing cell culture media including metabolomics, metabolic flux analysis
  • Experience with DOE (Design of Experiment)
  • Technological background in mammalian cell line development and cell culture process development
  • Strong interpersonal, presentation, time management, organizational and written/ oral communication skills are highly desirable
  • Previous experience working in cross-matrixed/functional teams and ability to work on complex effectively and collaboratively in a matrixed environment is an asset
  • Ability to successfully complete complex projects will be viewed favourably
  • Inventiveness, enthusiasm, motivation, and problem solving skills to develop new technical capabilities and solve challenging problems are assets

Every day, Lonza’s products and services have a positive impact on millions of people. For us, this is not only a great privilege, but also a great responsibility. How we achieve our business results is just as important as the achievements themselves. At Lonza, we respect and protect our people and our environment. Any success we achieve is no success at all if not achieved ethically. 

People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfaction that comes with improving lives all around the world. The satisfaction that comes with making a meaningful difference.


Reference: R33230
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