Scientist (All Levels) – Cell Culture/Engineering and Molecular Biology

United Kingdom, Cambridge

Today Lonza is a global leader in life sciences. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that’s the kind of work we want to be part of.

Would you like to join our global business where we invest in great people? 

Due to growth within Lonza, We are currently recruiting for Scientists of all experience levels to join our team of experts to compliment the cell engineering team in Cambridge. We are seeking candidates with a variety of skills and experience to work on projects that seek to improve the manufacturing of complex therapeutic proteins. In particular, to create recombinant CHO cell  lines and gene expression platforms with better performance characteristics.

In the cell engineering team we include scientists with a diverse range of skills and experience across a range of fields including cell and molecular biology, mammalian cell culture, recombinant protein  expression, protein engineering, and cell engineering (i.e. CRISPR-Cas9 genome editing). We  apply this experience to further the development of new and emerging technologies in the field of biologics manufacturing, we also provide an interface between key academic partners and the industrial environment.

These positions will require knowledge and understanding at varying levels, in mammalian cell culture, molecular biology and more specifically working with CHO (Chinese hamster ovary) cell lines and gene expression platforms.

These roles could be Perm or FTC (Fixed Term Contract) roles.

Key responsibilities:

  • Contribute to the delivery of new and/or improved CHO-based host cell lines and expression vectors for the production of complex therapeutic proteins
  • Innovation and technology development of new expression systems and related process development services; to include key cell culture techniques - mammalian cell culture, transient/stable transfections, fed-batch culture, and evaluation of cell lines by microfluidics/flow cytometry/ HT Bioreactors etc.
  • Collate, analyse, evaluate and sign-off data to produce good quality information and records
  • Present data in written reports oral presentations
  • Contribute ideas and opinions to scientific discussions to aid the development of new technologies
  • Work closely with other groups within R&D to deliver solutions or improvements in recombinant protein manufacturing (in particular with R&D Process Development and analytics)
  • Protein chemistry/analytical techniques (HPLC, electrophoresis, immunoassays etc.)
  • 80% lab based role using your practical industry experience and knowledge
  • Carrying out procedures using molecular biology skills including gene cloning and vector construction
  • Creating and/or manipulating mammalian expression vectors and expression systems; running various relevant cell culture systems e.g., static, suspension cell and bioreactor (Ambr) cultures

Key requirements:

  • PhD or BSc in relevant scientific / technical discipline - Experience in Life Sciences / Science/ Molecular Biology/ Biotechnology
  • Bioprocessing experience, either in industry or academia
  • Strong skillset in mammalian cell culture and molecular biology
  • Experience in lab automation, particularly cell culture and cell line development automation
  • Good working knowledge of statistics, expertise in design of experiments/multivariate techniques while not essential is desirable
  • Experience of generating stable cell lines/pools

Every day, Lonza’s products and services have a positive impact on millions of people. For us, this is not only a great privilege, but also a great responsibility. How we achieve our business results is just as important as the achievements themselves. At Lonza, we respect and protect our people and our environment. Any success we achieve is no success at all if not achieved ethically. 

People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfaction that comes with improving lives all around the world. The satisfaction that comes with making a meaningful difference.


Reference: R30912
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