R&D Lead Scientist - Cell Culture and Perfusion

United Kingdom, Slough

R&D Lead Scientist - Cell Culture and Perfusion

Lonza is a global leader in life sciences. We are more than 15,000 employees in more than 100 locations around the world. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that’s the kind of work we want to be part of.

Due to growth we are seeking scientists with an interest in continuous processing using mammalian cells to join our industry leading R&D team in helping to develop state of the art new therapies by driving down the cost of manufacturing through radical process innovation.

This is a unique opportunity to move your ideas from the thought world through our integrated continuous biomanufacturing sandbox to realisation in a new purpose built manufacturing facility.  You will use response surface optimisation techniques to develop a next generation continuous platform process incorporating state of the art PAT and automated feedback control.  You will work with world leaders to use high throughput automated bioreactor systems, to develop novel scale down models, to take multifactorial optimisation of bioprocesses to a new level and will be encouraged to publish and present your work internationally.  

The successful candidate will join a fast paced, results orientated, high-performing team, where the expectation is that the work will be delivered to the highest quality.  Whilst training will be provided previous experience in one or more of the following areas is expected: continuous or perfusion fermentation, miniature bioreactor operation, process control (preferably with Delta V).  In all cases strong numerical skills are expected.

Key responsibilities:

  • Planning experiments and writing up results and preparing presentations/reports (20%)
  • Practical – Cell culture, medium preparation and bioreactor operation (60%)
  • Laboratory maintenance and departmental meetings (20%)

Day to day activities:

  • Basic cell culture (revival, subculture and cryopreservation of cells and medium preparation)
  • Operation of automated miniature and laboratory scale bioreactors in batch and perfusion mode
  • Use of advance statistical experimental design and analysis techniques
  • Use of process analytical technology to accomplish feedback control of culture parameters
  • Keep an electronic laboratory notebook to a high standard
  • Contribute to the routine maintenance of the laboratory space and equipment

Key requirements:

  • A team-orientated person with a can-do attitude who is self-motivated and can work independently
  • Experience in a biologics manufacturing and knowledge of GMP would be preferred
  • Experience of perfusion and mammalian cell culture
  • Experience of Delta V would be and additional benefit
  • Someone who is excited about getting involved in cutting-edge research and has a passion for science
  • An individual focused on building a technical career in the Biopharmaceutical industry
  • Degree educated in biotechnology/biochemistry or chemical/biochemical engineering with relevant laboratory experience (preferably industrial)
  • Must be available to work around 1 weekend in 5 on a rota.

People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfaction that comes with improving lives all around the world. Together we can make a meaningful difference.

Reference: R25363