Research Associate - Process Development- Downstream

Houston, Texas

Today Lonza is a global leader in life sciences. We are more than 15,000 employees in more than 100 locations around the world. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that’s the kind of work we want to be part of.

The primary role of the Research Associate (downstream) at Lonza Houston is to operate chromatography and Tangential Flow Filtration (TFF) systems, execute experimental study plans, maintain accurate notes and analyze data that they generate. The person in this role should have a solid technical understanding of how to operate all relevant laboratory equipment, as well as prepare buffers. The person in this role should only require minimal supervision with respect to laboratory skills.

Key responsibilities:

  • Assist in the development and troubleshooting of scalable purification processes for viral vectors.
  • Support the technical transfer of processes to the manufacturing team.
  • Participate in authoring technical developments reports and presentations.
  • Participate in client-facing technical discussions relating to ongoing process development and manufacturing efforts.
  • Maintain good documentation with high level of detail, close-out experiments in a timely manner and work with fellow downstream team members to maintain the Process Development (PD) downstream labs in a professional working environment.
  • Perform experiments with limited supervision.
  • Participate in the design of experiments, discussion of experimental plans, and analyze data.
  • Prepare process development report drafts and tech transfer draft documents.
  • Prepare presentations for either team or client meetings.

Key requirements:

  • Bachelor’s degree in biochemistry, chemistry, chemical engineering, bioengineering, or related area and industry working knowledge experience required.  An Advanced Degree is preferred.
  • Hands-on experience of AKTA purification system or equivalent system is highly preferred.
  • Hands-on experience with the operation and development of TFF units is a plus; preferably using the SciLog system.
  • Demonstrated experience with the purification of biological molecules, such as viral vectors, therapeutic recombinant proteins, monoclonal antibodies or vaccines for biopharmaceutical applications is a plus.
  • Working knowledge and skills for viral vector or vaccine purification is a plus.
  • Ability to plan, organize, problem solve (troubleshoot), prioritize, work efficiently independently and in a team under tight timelines.
  • Scientific understanding or hands-on experience with analytical assays such as high pressure liquid chromatography (HPLC), spectrophotometry, sodium dodecyl sulfate – polyacrylamide gel electrophoresis (SDS-PAGE), dynamic light scattering (DLS), iso-electric focusing  (IEF) and polymerase chain reaction (PCR).
  • Experience of process characterization.
  • Statistical analysis, including design of experiment (DOE).
  • External publications and presentations.

People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfaction that comes with improving lives all around the world. The satisfaction that comes with making a meaningful difference.

Lonza is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a qualified individual with disability, protected veteran status, or any other characteristic protected by law.

Reference: R20468