Human Primary Cells for Biomarker Research

Primary cells are an essential component in research because they are derived directly from human and animal tissue representing a biologically relevant cell model. Unlike cell lines, primary cells have low modification/mutation rate and require minimal pre-characterization prior to use. Primary cells can be used as both normal controls to extensively characterize and validate your cell lines or they can solely act as superior substitutes to cell lines.


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Biologically relevant for biomarker discovery: Cell lines are prone to genotypic and phenotypic drift after continual passaging and many journals and government funding programs mandate cell line validation prior to use. Research shows, some cell lines may not be the cell type they have historically been reported. In a study of over 500 leukemia-lymphoma cell lines, 15% of the cell lines were misidentified. In a separate study, 18-36% of cell lines are found to be misidentified or cross-contaminated. For this reason, NIH mandates authentication of cultured cell lines as critical for grant applications to be considered of the highest quality.

In addition to pre-characterization, between 3-10 cell lines are required from same origin to build a comprehensive biomarker profile. This can drive up experimental costs significantly. Clonetics™ primary cells are extensively validated and make biomarker discovery more comprehensive. Primary cells typically retain cell surface markers and other genes relevant to actual human tissue. Eliminate costly analyses of inconsistent data acquired from non-characterized cell lines or low-quality primary cells.

Recent publication with Clonetics™ HUVECs: Neutrophil Gelatinase–Associated Lipocalin: A Novel Suppressor of Invasion and Angiogenesis in Pancreatic Cancer

Clonetics™ Primary Cells have been used by customers in various Cancer Research areas. Optimized Growth Media Kits are available with each cell type. Clonetics™ Cells and Media are tested together and are guaranteed to perform.


Lonza offers cells from the following tissues:

Blood & Lymph
Dermal (Adult and Neonatal)
Skeletal Muscle
Neural Cells
Neural Progenitors


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