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Use Clonetics™ Primary Cells for Cancer Formation Studies

Primary cells are an essential component in research because they are derived directly from human and animal tissue representing a biologically relevant cell model. Unlike cell lines, primary cells have low modification/mutation rate and require minimal pre-characterization prior to use. Primary cells can be used as both normal controls to extensively characterize and validate your cell lines or they can solely act as superior substitutes to cell lines.

Understand how cancer forms: Research shows primary cells can successfully be transformed into cancer cells through genetic mutations and expression of oncogenes. Replicate a cancer model in vitro using primary cells as prototypes of in vivo environment.

Study Cancer Stem Cells: Cancer stem cells (CSCs) are stem-cell like components that originate from normal tissue stem cells. CSCs share several properties with normal stem cells, such as their capacity for self-renewal and their ability to differentiate. CSCs, currently, can only be studied in primary cells or normal tissues as both contain sub-populations of stem-cell markers. Research also shows primary cells can be re-programmed into iPSCs and this is a vast area of study in cancer research currently.

Recent publication with Clonetics™ PrECs

  1. Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial
  2. The Role of CD133 in Normal Human Prostate Stem Cells and Malignant Cancer-Initiating Cells

Clonetics™ Primary Cells have been used by customers in various Cancer Research areas. Optimized Growth Media Kits are available with each cell type. Clonetics™ Cells and Media are tested together and are guaranteed to perform.


Return to Cancer Research


Learn more about primary cell culture and the cells and media Lonza offers