• Small Molecules
    • Services
      • Drug Substance (API)
      • Particle Engineering
      • Drug Product
    • Technologies
      • Highly Potent API (HPAPI)
      • ADCs
      • Spray Dried Dispersions
      • Micronization & Jet Milling
      • Inhaled Delivery (DPI)
    • Solutions
      • Early Phase API
      • Commercial Production API
      • Bioavailability Enhancement
      • Integrated Offerings
    • Knowledge Center
      • Webinars
      • Presentations
      • Publications
      • Meet the Experts
      • View all
    View all Small Molecules offerings
    View all locations
    Clinical drug development & preformulation

    Knowledge Center

    View all the latest resources


    Visit our Knowledge Center

  • Biologics
    • Modalities
      • Mammalian
      • Microbial
      • ADCs / Bioconjugates
      • mRNA / LNP
      • Drug Product
    • Technologies & Products
      • Expression Technologies
      • Discovery Products
      • Bioprocessing Products
    • Discovery and Preclinical
      • Early De-risking & Optimization
      • Cell Line & Strain Development
      • Process Development & Optimization
      • Analytical Development
      • Formulation Development
      • Non-GMP Manufacture
    • Clinical and Commercial
      • Process Development & Optimization
      • Formulation Optimization
      • cGMP Drug Substance Manufacture
      • cGMP Drug Product Manufacture
    Technical Support
    Regulatory Support
    View all locations
    View all Biologics offerings
    Woman and microscope

    Knowledge Center

    View all the latest resources available on site


    Visit our Knowledge Center

  • Cell & Gene
    • Services
      • Process Development
      • cGMP Manufacturing
      • Regulatory Consulting
      • Bioassay Services
      • Tissue Acquisition
    • By Modality
      • Autologous
      • Allogeneic
      • Viral Vectors
      • iPSCs
      • Exosomes
    • Technologies
      • MODA® Platform
      • Cocoon® Platform
      • Nucleofector® Technology
      • TheraPEAK® Media
      • Endotoxin and Pyrogen Testing
    • Knowledge Center
      • Webinars
      • Articles
      • Whitepapers & Publications
      • eBooks
      • Presentations
      • View all
    View all Cell & Gene offerings
    View all Bioscience Products
    View all locations
  • Capsules & Health Ingredients
    • Health Ingredients
    • Nutraceutical capsules
    • Pharmaceutical capsules
    • Capsule filling equipment
  • Contact
Small Molecules
Small Molecules
Services
  • Drug Substance (API)
  • Particle Engineering
  • Drug Product
Technologies
  • Highly Potent API (HPAPI)
  • ADCs
  • Spray Dried Dispersions
  • Micronization & Jet Milling
  • Inhaled Delivery (DPI)
Solutions
  • Early Phase API
  • Commercial Production API
  • Bioavailability Enhancement
  • Integrated Offerings
Knowledge Center
  • Webinars
  • Presentations
  • Publications
  • Meet the Experts
  • View all
Back
Biologics
Biologics
Modalities
  • Mammalian
  • Microbial
  • ADCs / Bioconjugates
  • mRNA / LNP
  • Drug Product
Technologies & Products
  • Expression Technologies
  • Discovery Products
  • Bioprocessing Products
Discovery and Preclinical
  • Early De-risking & Optimization
  • Cell Line & Strain Development
  • Process Development & Optimization
  • Analytical Development
  • Formulation Development
  • Non-GMP Manufacture
Clinical and Commercial
  • Process Development & Optimization
  • Formulation Optimization
  • cGMP Drug Substance Manufacture
  • cGMP Drug Product Manufacture
Back
Cell & Gene
Cell & Gene
Services
  • Process Development
  • cGMP Manufacturing
  • Regulatory Consulting
  • Bioassay Services
  • Tissue Acquisition
By Modality
  • Autologous
  • Allogeneic
  • Viral Vectors
  • iPSCs
  • Exosomes
Technologies
  • MODA® Platform
  • Cocoon® Platform
  • Nucleofector® Technology
  • TheraPEAK® Media
  • Endotoxin and Pyrogen Testing
Knowledge Center
  • Webinars
  • Articles
  • Whitepapers & Publications
  • eBooks
  • Presentations
  • View all
Back
Capsules & Health Ingredients
Capsules & Health Ingredients
Health Ingredients
Nutraceutical capsules
Pharmaceutical capsules
Capsule filling equipment
Back
Contact
Back
  • Home
  • Biologics
  • Expression Technologies
  • POTELLIGENT® CHOK1SV® Technology

POTELLIGENT® CHOK1SV® Technology

Improve the efficacy of your therapeutic candidates, by expressing antibodies with enhanced antibody-dependent cellular cytotoxicity (ADCC) with proven POTELLIGENT®CHOK1SV® technology. The POTELLIGENT® CHOK1SV® host cell line and subsequently derived recombinant cell lines exhibit good growth characteristics.
Contact us
Produce more potent and effective cytotoxic therapeutic antibodies

In the growing field of therapeutic antibodies, drug developers are continually searching for new strategies to improve efficacy. Optimization of antibody molecules by Fc engineering is a major opportunity in this area. Potency can be increased by enhancing antibody-dependent cellular cytotoxicity (ADCC). 100% fucose-free antibodies in glycan moieties show much higher ADCC activity than normally fucosylated antibodies.

Through our partnership with BioWa, we can help you take advantage of this strategy. By fully removing fucose content, BioWa’s POTELLIGENT® Technology can increase the potency and efficacy of your antibody drugs. The POTELLIGENT® CHOK1SV® cell line technology enables the rapid expression of highly productive and stable recombinant cell lines

Read Article

Access to industry-leading technologies

Through our partnership with BioWa, we can help you take advantage of our established CHOK1SV® cell line lineage. By fully removing fucose content, BioWa’s POTELLIGENT® Technology can increase the potency and efficacy of your antibody drugs.

The POTELLIGENT® CHOK1SV® cell line is available under a license.

Contact us to find out more.

Related Technologies

GS Xceed® Gene Expression System
Our GS Gene Expression System® is a market-leading CHO based protein expression technology platform....
Learn More
GS piggyBac® Transposon Technology
We provide unique and versatile transposon based cell line engineering technology that combined with...
Learn More
bYlok® Bispecific Pairing Technology
Lonza’s bYlok® platform technology was developed to help solve mispairing in bispecific antibodies.
Learn More
XS Technologies® | Pichia & E.coli Expression
Our versatile XS Technologies® offer an extensive microbial expression toolbox, including the XS®...
Learn More
Expression Technical Support
Technical support for your development journey, based on over 35 years of expertise in protein...
Learn More
Our locations

Our R&D Centers of Excellence

Explore all locations
Cambridge, United Kingdom
Cambridge, United Kingdom
Visp in the Fall
Visp, Switzerland
Slough exterior
Slough, UK
Haifa, Israel
Haifa, Israel
Explore all locations
Biologics

Knowledge Center

Knowledge Center
Poster
Lift your CLC Expectations to a New Level
Reducing time from gene to IND is an important consideration in developing new processes and...
Article
StarMab to Use Lonza’s XS® Pichia Platform to Express Their Proprietary Multifunctional VHH...
Beijing StarMab BioMed Technology Ltd. (StarMab) has entered a research evaluation agreement with...
Knowledge Center
Ways to Contact
  • Contact Us
  • Regulatory Support
  • Locations
  • Partnering with Us
Resources
  • Knowledge Center
  • Meet the Experts
  • Upcoming Events
Terms & Conditions
  • Terms and Conditions
  • Legal Disclaimer
  • Privacy Policy
  • California CCPA Notice
  • Transparency in Coverage
Lonza.com
  • Company Overview
  • News & Media
  • Investor Relations
  • Sustainability
  • Careers
  • Sitemap
© 2023 Lonza. All rights reserved.