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type of pyrogen, are natural compounds found in the outer cell membrane of
Gram-negative bacteria and can impact over 30 biological activities. Endotoxin
can lead to cell death by initiating complement activation.
The Limulus Amebocyte
Lysate (LAL) test was commercially introduced in the 1970s. LAL is derived from
the blood cells, or amebocytes, of the horseshoe crab, Limulus polyphemus. Frederick Bang and Jack Levin
observed that blood cells from horseshoe crabs were found to clot in the
presence of endotoxin, and this technology was used in the development of
endotoxin detection assays. Today,
endotoxin tests are performed on raw and in-process materials, and for the
final release of products in the pharmaceutical and medical device industries.
experience with endotoxin detection and its regulatory requirements, Lonza has
been able to deliver innovative and time-saving tools for both the
pharmaceutical and research markets.
We offer a wide
range of endotoxin detection assays, based on your testing needs, each with their
own unique benefits:
appropriate endotoxin detection assays may not be an easy choice. The Endotoxin
Assay Selection Guide, located in the QC Insider™ Library, can help you
determine which assay is best suited for your testing needs. Explore our
comprehensive support tools in the QC