ResistAid™ is a proprietary natural immune support ingredient. It is produced via a patented water-based extraction process (US 5756098, EP 866808 and other patents) from larch trees that grow in abundance in the United States. ResistAid™ consists of the soluble fiber arabinogalactan and bioactive flavonoids, and thus has antioxidant capacity.
Products displaying the ResistAid™ quality seal on the packaging show that they contain the natural immune ingredient from Lonza.
- Proprietary, natural immune support from larch trees
- Year round, triple action immune support (direct, indirect and antioxidant capacity)
- Ability to modulate and support appropriate immune response
- Soluble dietary fiber
The immune system is a highly complex and interrelated system that has two pathways to address foreign substances. The innate arm of the immune system is non-specific and targets anything that is viewed as foreign to the body whereas the adaptive system targets specific foreign substances. Both immune arms work together to protect the body against foreign substances.
Clinical study results indicate that larch arabinogalactan has the ability to modulate and support the two arms of the immune system in a positive manner through direct and indirect pathways within the gastrointestinal tract, so that the components of the different arms are optimized and appropriately respond when challenged by a foreign substance. The mechanisms of this effect have been investigated and seem to include not only the indirect effects of lactic acid-producing bacteria and bacterial constituents on immune cells, the production of short chain fatty acids (SCFAs) and binding to SCFA receptors on leucocytes, but also direct effects on components of the immune system.
Specifically, the activity of natural killer cells, cytokines and macrophages may be supported by larch arabinogalactan supplementation. In addition, ResistAid™ has antioxidant capacity which can be related to its content of polyphenolics.
Interestingly, several immune “enhancer” herbs contain significant amounts of arabinogalactan, such as Echinacea purpurea, Baptisia tinctoria or Thuja occidentalis and researchers speculate that this is one of the main immune-activating principles in these herbs.
Natural Immune Function Support
ResistAid™ supports natural immune function by increasing beneficial immune cell populations and/or increasing antibody production based on the immune stressor. ResistAid™ has the ability to support and strengthen the appropriate immune response based on the immune stressor.
Support of Innate Immune Response
Support of Natural Killer Cells
Natural killer cells (NK cells) are a type of cytotoxic lymphocytes which constitute a major component of the innate immune system. NK cell activity is a functional marker for health. In mice, i.p. administration of arabinogalactan from larch during a 2-week period has been found to stimulate NK cell activity. Pre-treatment of human peripheral blood mononuclear cells with larch arabinogalactan has shown enhancement of NK cytotoxicity which was found to be governed by the cytokine network.
Support of Cytokines
Larch arabinogalactan can act as an inducer of the production and/or the release of various cytokines. In cell culture, larch arabinogalactan induced an increased release of interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6). It was found that the IFN-gamma was most responsible for the observed enhancement of NK cytotoxicity.
Support of Macrophages
Macrophages are important in the body’s defenses. They originate from specific white blood cells called monocytes. Monocytes and macrophages are phagocytes, meaning they destroy harmful organisms. Larch arabinogalactan administered to healthy human subjects in combination with a standardized Echinacea extract was found to significantly increase human circulating peripheral blood monocytes (PBMC). As shown in in vitro studies arabinogalactan from various sources can also activate macrophages.
Support of White Blood Cells
Research has shown that supplementation with larch arabinogalactan can increase total white blood cell counts, mostly by increasing the neutrophil concentration.
Support of Adaptive Immune Response
Latest research shows that the immune benefits of ResistAid™ additionally include the adaptive immune response, a response to specific antigens. The study was designed to test the hypothesis that ingestion of ResistAid™ would selectively enhance the antibody response to a vaccine in healthy adults. Vaccination studies of this type serve as a model to study the effect of nutraceutical supplementation on the overall immune function. The group that ingested ResistAid™ demonstrated a higher IgG Ab (immunoglobulin G antibody) response to the vaccine than the placebo group in two Ab subtypes during the 10 weeks following vaccination. The study further showed that ResistAid™ may have an immunomodulatory effect, meaning it supports the appropriate response to an antigen without indiscriminately enhancing other arms of the immune system that would not be expected to respond.
Natural Antioxidant Properties
Dietary antioxidants, including polyphenolic compounds, are regarded as effective nutrients in the prevention of health concerns related to oxidative stress. Phenolics or polyphenolics are responsible for most of the antioxidant capacity in fruits, vegetables and most botanical antioxidant supplements. It is recognized that polyphenolic flavonoids are able to scavenge different reactive oxygen radicals, such as hydroxyl and superoxide radicals. The polyphenolic flavonoids present in ResistAid™ include taxifolin and quercetin, which have been shown to display a wide range of biochemical properties, including antioxidant and chemoprotective effects.
ResistAid™ Quality and Safety
ResistAid™ Quality at a Glance
- Solvent free, water-based extraction process
- Manufactured according to HACCP principles
- GMP audited by American Institute of Baking
- Kosher certified by United Mehadrin
- GMO free
- Monograph in Food Chemicals Codex (FCC)
ResistAid™ Safety at a Glance
- Self-affirmed GRAS with US FDA notification
- Approved by the US FDA as a direct food additive
- Allergen free
- No reported side effects, no adaptation period required
ResistAid™ is produced by steamheating larch chips to extract the phenolic and arabinogalactan compounds and evaporating the resulting extract. This water-based extraction method is patented (US 5756098, EP 866808 and other patents) and is unique as it does not require any harsh chemicals to release the compounds from the plant matrix. Therefore, the product remains pure and structurally unaltered after extraction.
As a raw ingredient manufacturer, we actively promote our ingredients on a business-to-business level.
Our regulatory experts collaborate with authorities and organizations globally to work towards a regulatory situation that is in favor of ResistAid™ products. We have years of experience with regulatory dossiers and a track record of successful regulatory initiatives.
ResistAid™ has a number of technical properties which make it easy to incorporate into dietary supplements and functional foods in standalone form or combined with other products to increase functionality.
High solubility in water
As ResistAid™ has a highly branched structure it is freely soluble, dissolving completely in hot or cold water.
Stable to temperature and low pH value
ResistAid™ is stable at a wide range of temperatures and pH, which provides for use in various applications. In beverages it keeps its functionality and neither degrades nor hydrolyzes.
Ask us how ResistAid™ can be incorporated into your application.
Lonza works in collaboration with universities and research centers around the world to strengthen the scientific backing of ResistAid™. We maintain a database of published literature which is used by our technical experts to provide tailor-made, well-researched answers on technical questions.
Please contact our scientific experts to get more details about the applications and technical benefits of ResistAid™ to support your project.