Poietics™ Immune Cells

Each product is offered as a single donor per ampoule and multiple donors are frequently available for each product.

Matched sets of two or more different cell types from the same original donor may be available. Please contact Scientific Support to inquire if matched sets are available.

Lonza's LGM-3™ Lymphocyte Growth Medium is an appropriate, serum-free culture medium for lymphocyte cell growth.

The human body is constantly bombarded by foreign pathogens which pose the risk of causing disease. Nearly all species of life have developed a system to respond to and eradicate or neutralize invading pathogens. This defense system, typically known as the immune system, is critical to maintaining the health of an organism. Many of these foreign pathogens have developed means to adapt and evolve rapidly resulting in an ever changing population of pathogens constantly attempting to infect and inhabit the host. Higher level species, including humans, have developed a complex immune ability known as adaptive (or acquired) immunity which allows the host to respond to these evolving threats and provide an immunological memory to react against future infection attempts by species (or similar species) of pathogen which the body has previously eradicated.

Issues related to the immune system can include immunodeficiency diseases, including HIV/AIDS, where the host has lost the ability to provide an immune response or has an inhibited immune response and autoimmunity diseases where the host’s own immune system attacks healthy tissue.

Lonza offers a wide variety of cells involved in the immune system including dendritic cells, monocytes, natural killer cells, and lymhocytes. Poietics™ Primary Human Immune Cells and Media are isolated from either peripheral blood or cord blood from healthy donors. Each donor is tested and found non-reactive by an FDA approved method for the presence of HIV-I, Hepatitis B Virus and Hepatitis C Virus. Where donor testing is not possible, cell products are tested for the presence of viral nucleic acid from HIV, Hepatitis B Virus, and Hepatitis C Virus. Poietics™ Primary Human Immune Cells purity levels are verified via flow cytometric analysis.

Applications

  • Transplantation
  • Autoimmune diseases
  • HIV/AIDS
  • Cellular immunity
  • Immunotherapy
  • Cancer
  • Cell Memory
  • Diabetes Type I
  • Histocompatibility
  • Graft-versus-host disease