Image of white blood cells and red blood cells

The Immunotherapy and Hematopoietic Knowledge Center is dedicated to sharing interesting articles and resources related to hematopoietic research. Click on the links below to explore different articles. 

If there is a topic you would like to see highlighted, please send an email to hematopoietics at lonza.com.


Visual of B and T cells suppression of allergic reactions

Allergen Immunotherapy to the Rescue

 

The number of people worldwide suffering from some form of allergy is extremely high. For some of these allergy sufferers, allergen specific immunotherapy (allergen-SIT) has provided more than temporary relief.

 

The immunological mechanism of allergen-SIT is essentially the induction of persistent specific allergen tolerance. The allergen-specific memory T and B cell responses are altered, leading to immune tolerance. Read more...


 hIL-17 secretion determination graph

Validation of TH17 Cell Differentiation from Peripheral Blood CD4+T Cells

 

The combination of differentiation procedure, cells, assessment methods and instrumentation provide a simplified, robust process for the creation and validation of activated immune cells. Read more...


Chimeric antigen receptors

A Molecular Spotlight on CAR-T Cells

 

Chimeric antigen receptor-redirected T cells (CAR-T cells) have become a promising tool in the treatment of hematopoietic malignancies as well as solid tumors.

 

CARs expressed on T cells target surface antigens in their native conformation, independent of the major histocompatibility complex. In CAR-T cell therapies the collection of patient’s T cells is followed by  Read more...


msc infographic thumbnail

Mesenchymal Stem Cells Infographic

 

Mesenchymal stem cells can differentiate into chondrocytes, adipocytes, and osteoclasts. They have extensive uses in both regenerative medicine and immunotherapy research Read more...


Image of NK cell subsets based on expression of CD56 and CD16

Natural Killer Cells Infographic

 

Natural Killer cells have an innate ability to recognize and destroy non-self cells. They are characterized as CD3- CD56+.  NK cell subsets are characterized by their expression of Read more...


schematic describing current genetic modification strategies to optimize nk cells for use in immunotherapy

Natural (Born) Killers - NK Cells in Immunotherapy 

 

Natural Killer (NK) cells are aptly named. They act like well-trained snipers, ready to target and destroy foreign cells at the drop of a hat.

 

They do not require prior sensitization, or exposure to foreign antigen, in order to kill. Instead, they have an innate, natural ability to recognize and destroy non-self cells.  

 

NK cells are broadly characterized as Read more...


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PBMCs - The One Stop Immune Cell Shop

 

PBMCs are a mixed population of myeloid and lymphoid cells. The myeloid cells include monocytes, dendritic cells, and macrophages. Monocytes circulate through the blood to different tissues, where they differentiate into tissue-resident macrophages and dendritic cells.

 

Macrophages are the Pac-Man cells of the immune system that engulf and destroy foreign substances and cancerous cells. There are resident macrophages that maintain a steady-state of general tissue repair. In addition, there are also Read more...


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Cord Blood-Derived HSCs - The Quest to Overcome Limited Cell Numbers 

 

Bone marrow and peripheral blood-derived HSCs allow for large numbers of CD34+ cells to be harvested and transplanted, but they are of limited utility if an HLA-matched donor is unavailable. Cord blood-derived hematopoietic stem cells offer a potential solution, as the cells tend to be more naïve, which may lead to fewer occurrences of host-versus-graft-disease (GVHD) in instances of HLA-mismatch.

 

Despite their potential in combating GVHD, cord blood-derived HSCs also pose a major challenge due to the limited number of cells available from Read more...


CD4+ helper T cell subsets image

T Cells - An Orchestrated Motley Crew 

 

The immune system is an intricate and fascinating network of many different cell types and signaling molecules that work together to protect the human body against foreign pathogens.

 

T cells are responsible for regulating the immune response, and much like a motley crew, they possess Read more...