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Real Bone. Better Results
High-throughput analysis of bone resorption activity
Osteoporosis is a metabolic bone disease characterized by the deterioration of bone tissue and low bone mass density leading to bone fragility and risk of fracture. A significant part of osteoporosis research involves the search for new drugs to inhibit osteoclastic bone resorption.
The OsteoAssay™ Human Bone Plate provides the convenience of a high-throughput plate matrix that can be used to quantitatively measure bone resorption.
The OsteoAssay™ plate provides a thin layer of adherent human bone for the culture of primary human or non-human osteoclasts, osteoclast precursors, or immortalized cell lines. Cells can be stained with standard cytochemical (e.g. TRAP) or immunofluorescent techniques. Assays of bone resorption (e.g. EIA of collagen telopeptides), and osteoclast precursor differentiation (e.g. TRAP enzyme activity) can be performed easily by sampling the cell culture supernatant.
Novel - Contains real human bone for more biologically relevant results
Convenient - Ready-to-use plates with human bone chips attached to wells eliminates the need for dentine or bone slices
Simple - Cells can be seeded onto the surface of the OsteoAssay plate and used in traditional cell culture protocols
Flexible - Can be used with a variety of cell types and cell-based assays