than half a century, Lonza has been one of the world’s leading producers of
nutritional ingredients and vitamins. In the early 1980s, Lonza scientists
discovered a unique way for the biotechnological production of L-Carnitine on a commercial scale. Today, we are a leading manufacturer of
active and functional ingredients for the agriculture, nutrition, cosmetic, personal care,
biotech and pharmaceutical industries.
derived products such as biopesticides, biostimulants and other microbial
active ingredients, as well as biologically derived intermediates for
subsequent chemical conversion are of growing interest for the crop protection
our fermentation and process development services offer you the most advanced
technologies, capabilities and experience in the industry. Whether for
small-scale development projects or commercial-scale market leadership, our
unparalleled experience, cutting-edge facilities, commitment to quality,
innovative nature, dedicated project management, and green thinking help your
fermentation product reach its full potential.
Lonza’s more than 30 years’ experience and expertise in biological processing
and our track record in the agricultural area, we offer our customers a full
“one-stop-shop” service package at all stages of development and production.
have an idea of a specific target molecule, you have an initial strain and process
to be further improved, you need general consulting, for any request we develop
together with you the most suitable service program.
you need a few tons for your launch phase, or you request commercial volumes,
we offer you a reliable technology transfer into our manufacturing assets, and
take full responsibility for in-time and in-spec delivery of your product.
sites in Visp, Switzerland, and Kouřim, Czech Republic, over 200 highly
qualified experts are dedicated with their passion and motivation to deliver
out-standing results. Backed by Lonza’s
reliability, quality and service guarantees, we help you maximize the
financial benefit of your product.
Lonza’s fermentation and associated downstream process facilities are
located in Kouřim, Czech Republic. On a site area of more than 80’000 m2,
we provide a total fermentation capacity of 475 m3 with the
associated recovery and purification equipment, an integrated waste water
treatment plant and also our dedicated R&D and analytical groups as well as
all other service functions.
complies with all relevant industrial standards (HACCP, Kosher, FAMI-QS, cGMP
and ISO 9001:2008) and is inspected on regular base by
authorities, e.g. FDA, SQS and also our customers.
We can offer 24h production
1) Fermentation manufacturing capacities:
x 15m3 BSL-2
2) Associated downstream processing
flow filtration units (Micro-, Ultra-, Nano- & Reverse osmosis)
3) Ex-proof facilities (DSP 2x50m,3
2x75m3 and 3x50 m3)
& Product Experience:
Technologies™ for Microbial Expression
- Therapeutic Proteins (for oral
& topical applications)
- Secondary Metabolites
- Modified Peptides
- Enzymes & Biotransformation products
- Lyophilized or Frozen Cultures
- Biomass Products
- Staphylococcus sp.
- A dozen other microbial species,
including BSL-2 organisms
Process Development & Scale-Up
Lonza has a
wide range of experience with a variety of microbial organisms, including bacteria,
fungi and microalgae. We can develop, transfer and/or optimize process unit
operations. Lonza has the ability to produce under ISO/Food/Feed standards. We
offer full life-cycle project management - from development stage to full-scale
in-market supply and from strain development to regulatory submission support.
understand that the road to an efficient commercial manufacturing process
starts with the right process development program. Our multi-disciplinary
process development team is constantly focusing on economic viability,
robustness, scalability and conformation to the regulatory requirements of the
processes right from the beginning. Our process development teams in Visp,
Switzerland have some of the most extensive fermentation know-how in the
industry, having developed over 100 processes, 25 of them large-scale.
technologies we use for strain improvement are as follows:
Mutation Technology – rational & random mutagenesis, genome shuffling (non
DNA Technology – metabolic engineering (GMO)
- Lonza’s proprietary XS Technologies™ for
Process Development and Media Design
Biocatalytic Toolbox (>700 wild type strains and wide range of enzymes)
biotech and chemical process development
DSP & Formulation
of product recovery & purification processes (e.g. membrane technologies,
biomass separation, filtration, extraction,
crystallization, drying and chemical modifications)
technologies (e.g. spray drying and encapsulation)
development for in-process and final product analysis
range of equipment for scale-up studies
Modelling of unit operations and full process
- Manufacturing of pilot volumes