Malononitrile is extensively used as a building block for the synthesis of vitamins, agrochemicals, pharmaceuticals and dyes. The two most important outlets for malononitrile are thiamine (vitamin B1) [59-43-8] and the sulfonylurea herbicides based on 2-amino-4,6-dimethoxypyrimidine [36315-01-2], such as benzsulfuron-methyl, azimsulfuron [120162-55-2], pyrazosulfuron-ethyl [93697-74-6]and halosulfuron-methyl [100784-20-1].
Other outlets for malononitrile are the diuretic triamterene [396-01-0], the folic acid antagonist methotrexate [59-05-2], both prepared from 2,4,6-triaminopyrimidine [1004-38-2](34), adenine [73-24-5], the antihypertensive minoxidil [38304-91-5], and the pesticide dicyclanil.
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