Accessing the XS™ Technologies

  • Introduction

    Accessing the XS™ Technology Platform is easy.  Under a Research Evaluation Agreement (REA) customers will have access to Lonza’s microbial expression hosts and vectors in their own development laboratories. The research agreement includes licensing options for both E. coli and Pichia systems, along with detailed fed-batch fermentation protocols designed to quickly create commercially-viable production strains and cGMP processes.  The kit contains all the components necessary to identify the best production clone for your product.  In addition, there are numerous options for technical support including: notification of system upgrades, visits to customer sites as part of XS™ Technology tours, and access to technical experts by phone or e-mail.

    The REA is renewable on an annual fee basis for as long as you have XS™-expressed products in preclinical stages. This fee covers access to 5 E. coli and Pichia systems.  Once you are ready to file an IND/IMPD for a therapeutic or vaccine candidate, an XS™ Commercial License must be obtained.   This license covers the clinical development and commercial stages for the candidate drug.

    To set up an XS™ REA, simply e-mail Lonza at xstechnologies@lonza.com and a representative will contact you.

  • XS™ E. coli REA System Options

    Lonza's XS™ E. coli REA includes the systems mentioned below.*  Our technical experts can work with you to determine the microbial expression systems that best meet your needs.

    *System availability varies by country.

     

  • XS™ Pichia REA System Options

    Lonza's XS™ Pichia REA includes the systems mentioned in the table below.*  The expanded REA is complemented with the following proprietary elements:

    • Novel signal peptides that eliminate N-terminal variant formation
    • Novel constitutive promoter, stronger than the state-of-the-art and widely-used pGAP promoter
    • Novel glucose regulated promoter variant with 5-10 times better performance than the wild-type promoter

    Our technical experts can work with you to determine the microbial expression systems that best meet your needs.

    *System availability varies by country.