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Lonza’s Epibase™ In Silico platform is a patented T cell epitope screening tool for the identification of potential epitopes in biotherapeutic protein and antibody targets. The tool is driven by sequence information, structural bioinformatics, and experimental data. The Epibase™ In Silico tool uses structural characteristics of the HLA receptor along with experimentally determined binding affinities to predict potential peptide/HLA binding, a condition necessary for T cell activation.
The Epibase™ In Silico tool supports lead candidate selection, ranking, optimization, and design for the development of biotherapeutic proteins and antibodies with reduced immunogenicity risk.
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