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Following the successful development of the Potelligent® CHOK1SV cell line by scientists at KHK and Lonza, the power of a Potelligent® mAb is available with the industry standard GS Gene Expression System™.
The Potelligent® CHOK1SV cell line has similar properties to the parental CHOK1SV cell line and has been shown to produce entirely fucose-free antibodies with the expected ADCC enhancement. Potelligent® CHOK1SV has undergone extensive trials in Lonza’s processes with a range of antibodies. A full range of protocols is available for the creation of highly productive cell lines.
Figures 1 and 2: Growth and productivity characteristics of CHOK1SV and Potelligent® CHOK1SV derived cell lines in 10L fed-batch bioreactors (cell lines producing the same antibody).