ADC Sample Preparation

ADC Sample Preparation

Reach Our ADC Experts:

adc@lonza.com

  • Introduction

    Our Commitment to Your Pipeline

    Lonza is proud to offer more ways than ever to deliver your product quickly and efficiently.  Our new streamlined online ordering system for the rapid synthesis of your small scale antibody drug conjugate samples is now available. Your conjugation will be performed in a dedicated safety laboratory by our technical professionals.

    The typical turnaround time for our new ADC service is 5 weeks after reception of the mAb and toxin. A 10% discount will be applied for every week of delivery delay after 5 weeks.

     

    Return to ADC R&D Services

  • Cysteine Conjugation Technology

    Scope of Work

    • Charging 2-8 mL of antibody solution in the vessel (as provided)
    • Adjustment of pH
    • Addition of TCEP solution and reduction
    • Addition of linker-toxin solution in DMA and reaction
    • Quench with N-acetyl-cysteine solution
    • Purification over desalting column, formulation using selected buffer
    • ADC analysis with the following generic assays: monomer purity by SEC/drug-to-antibody ratio by HIC/endotoxin
    • Sample shipment (on dry ice) in 5-10 mL PETG bottles, together with analytical results

     

    Pricing

    • 1 sample: CHF 6.500
    • 2 samples: CHF 11 .000
    • 3 samples: CHF 15.000
    • 4 samples: CHF 18.500
    • For every additional sample: CHF 3.000

    Note: Development work not included

    Request ADC Sample Preparation Services

  • Lysine Conjugation Technology

    • mAb modification with SMCC followed by conjugation with thiol-based toxin (coming soon)
    • mAb modification with SPDB followed by conjugation with thiol-based toxin (coming soon)
    • mAb modification with 2-iminothiolane followed by conjugation with maleimide-based linker-toxin (coming soon)
    • mAb modification with SATA followed by conjugation with maleimide-based linker-toxin (coming soon)