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Primary human bone marrow hematopoietic progenitors are multipotent cells that can differentiate into several lineages (e.g., myeloid,erythroid and megakaryocytic cells). The myeloid, erythroid and megakaryocytic EasyDiff™ Supplements allow differentiation of CD34+ cells into three different hematopoietic lineages in 96-well plates.
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These EasyDiff™ Supplements can be used for both drug discovery and toxicology. Bone marrow progenitors are extremely sensitive to the toxic side effects of many drugs. Early discovery and elimination of toxic compounds is an important component of the drug discovery process. Studies have shown that the inhibitory activity of several drugs, as measured in in vitro assays of hematopoietic progenitor differentiation, correlate with their in vivo activities in various animal models (Volpe, 1996; Parchment, 1194). Toxic effects of drugs can also be lineage-specific (Scheding, 1994; Silverstein, 1988).