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Lonza provides the CAR-T market with end-to-end solutions for successful commercialization. This includes tools that can be used to develop and test therapeutics, ranging from cell culture and discovery technologies to quality control tests and process optimization. One of the latest additions to the portfolio is the 4D-Nucleofector™ LV-Unit . Designed to provide a closed system in which to transfect cells and successfully generate various cell types that can be used in the CAR-T process and beyond.
Thank you for visiting our Lonza Booth at the 2016 CAR-TCR Summit. Explore how we can support your CAR-T research.
4D-Nucleofector™ LV Unit
The LV Unit, a new functional unit for the 4D Nucleofector™ System, allows for closed, scalable transfection of larger cell numbers in the range of 1x107 to 1x109 cells. Transfection protocols can be established in smaller scale using the X Unit and subsequently transferred to the LV Unit without the need for re-optimization.
Hematopoietic Cell Medium that provides nutritionally complete and balanced environments for a variety of cells. X-Vivo™ Medium has also been shown to work well with T-cells in a variety of CAR-T applications with the addition of specific supplements.
X-VIVO™ Medium is available in three formulations:
Coming soon: New T-cell specific X-VIVO™ Medium
Lonza’s CMO Services
Lonza Custom Manufacturing services extend across the entire
value chain of the CAR-T sector.
Raw material supply of high quality GMP viral particles for
successful on-demand immune cell transduction includes development of your
virus seed through process validation.
With 20 years of viral GMP manufacturing experience (AAV,
adeno, lenti, and others), we can supply product to cover our clients’ needs
from preclinical to commercial application.
Our process development scientists work hand-in-hand with
our clients to develop client-specific custom protocols using a variety of
We meet each unique need, encompassing every aspect of the
business from raw material requirements, process flow, scalability, closed
systems, automated vialing, to storage and distribution.