Switzerland, 1 December 2014 – Lonza today
announces the publication of the results of two early pilot studies performed using
soy lecithin-derived phosphatidylserine (PS) and phosphatidic acid (PA), which
appeared in the November issue of Advances
in Therapy. The results of both studies provide evidence suggesting a
combination of PS and PA – as in Lonza’s proprietary MemreePlus™ ingredient – can
support memory and cognitive function, which is especially apparent in those
who have developed cognition deficiencies. The publication of the results can
be found here: http://link.springer.com/article/10.1007%2Fs12325-014-0165-1
Since 2011 Lonza and
PS supplier Lipogen LTD have worked together under an exclusive distribution
agreement to offer Lipogen’s PS products as Lonza MemreePS™ ingredient. The two
previously unpublished, early
pilot studies funded by Lipogen used a combination of 100 mg PS and
80 mg PA three times per day.
The first study, a
three-month, double-blind, placebo-controlled study with PS and PA in 72
functioning, non-depressive elderly with memory problems, demonstrated a
statistically significant positive influence of PS and PA on memory, mood and
cognition in pre-post comparison.
The second study,
a two-month, randomized, double-blind, placebo-controlled study with PS and PA
in 96 patients with Alzheimer’s disease, demonstrated a significant stabilizing
effect of PS and PA on daily functioning, when comparing both groups. There
also were some improvements in emotional state and self-reported general
condition in the PS + PA group; no negative side effects were observed.
At the conclusion
of the studies, the combination of PS and PA demonstrated a positive influence on
memory, mood and cognition among elderly test subjects with memory problems.
Therefore, the data encourage long-term studies with PS and PA in Alzheimer’s
patients and other elderly with memory or cognition problems.
Additionally, the studies
show PS is efficiently absorbed after oral consumption. Specifically, the
studies showed serum PS peaked 90 minutes after ingestion, returning to
baseline after 180 minutes.
“The sum of these
studies validates MemreePlus™ ingredient, Lonza’s proprietary blend of
soy-based PS and PA, for formulation into nutritional supplements as a memory and
cognitive support ingredient,” said Matthias Ruesing, PhD, Global Product
Manager for the Memree™ product line at Lonza. “We will continue to further investigate
the benefits of MemreePS™ and MemreePlus™ PS+PA, alongside our continued
research being conducted with our entire nutrition ingredients portfolio.”
Earlier this year
another published study confirmed that supplementation with MemreePlus™ ingredient
can support a normal stress response in chronically stressed male adults. Those
findings were published in Lipids in
Health and Disease and can be found here: http://www.lipidworld.com/content/13/1/121/abstract.